Ohgane Kenji

オオガネケンジ | Ohgane Kenji

Affiliation and department：

Research field (7)： Bioorganic chemistry , Structural/physical organic chemistry , Molecular biochemistry , Cell biology , Chemical biology , Pharmaceuticals - chemistry and drug development , Pharmaceuticals - chemistry and drug development

Research theme for competitive and other funds (4)：

2020 - 2023 生理的なタンパク質安定性制御機構への介入による新奇コレステロール合成調節剤の創製
2017 - 2020 Analysis of off-target activities of an anti-fungal drug Itraconazole
2014 - 2015 Identification of pharmacological chaperone drugs for Niemann-Pick type C through image- based, drug re-purposing screening
2010 - 2012 タンパク質のフォールディングを促進する低分子化合物に関する医薬化学的応用研究

Papers (22)：

Ryuta Shioi, Fumika Karaki, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Minoru Ishikawa, Kosuke Dodo, Yuichi Hashimoto, Mikiko Sodeoka, Kenji Ohgane. Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs. PLOS ONE. 2020. 15. 12. e0243746-e0243746
Yosuke Toyota, Hiromasa Yoshioka, Ikuya Sagimori, Yuichi Hashimoto, Kenji Ohgane. Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation. Bioorganic & Medicinal Chemistry. 2020. 28. 14. 115576-115576
Hiromasa Yoshioka, Hudson W. Coates, Ngee Kiat Chua, Yuichi Hashimoto, Andrew J. Brown, Kenji Ohgane. A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate. Proceedings of the National Academy of Sciences. 2020. 117. 13. 7150-7158
Ikuya Sagimori, Hiromasa Yoshioka, Yuichi Hashimoto, Kenji Ohgane. Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols. Bioorganic & Medicinal Chemistry. 2020. 28. 3. 115298-115298
Hiroko Yamashita, Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa. Application of Protein Knockdown Strategy Targeting β-Sheet Structure to Multiple Disease-associated Polyglutamine Proteins. Bioorganic & Medicinal Chemistry. 2019. 28. 1. 115175

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MISC (5)：

大金賢司. タキソール誘導体の新たな有用性:ほ乳類細胞における半数体細胞の維持. ファルマシア. 2020. 56. 4. 345-345
特集: 標的蛋白質の構造を安定化するシャペロン薬 (取材協力・インタビュー). 日経バイオテク. 2019. 2019.4.22. 4-8
石川稔, 友重秀介, 野村さやか, 山下博子, 大金賢司. 神経変性疾患原因タンパク質のケミカルノックダウン. MEDCHEM NEWS. 2018. 28. 2. 88-92
大金賢司, 唐木文霞, どど孝介, 橋本祐一. タンパク質の折り畳みの異常を直すファーマコロジカルシャペロン-ニーマンピック病C型治療薬を目指した取組み-. 現代化学. 2013. 512. 48-54
沼館慧剛, 三田裕介, 大金賢司, 松本洋太郎, 橋本祐一. ハンチントン病治療を指向したDrp1阻害薬の創製. 日本薬学会年会要旨集(CD-ROM). 2013. 133rd. ROMBUNNO.29K-AM14

Patents (3)：

Method For Concentrating and Refining Alkyne-containing Molecules
ニーマンピック病C型予防及び/又は治療剤
ベンズアルデヒド化合物

Books (1)：

膜タンパク質工学ハンドブック (監修: 津本浩平、浜窪隆雄)
(株)エヌ・ティー・エス 2020 ISBN:9784860435370

Lectures and oral presentations (40)：

Discovery and applications of pharmacological chaperons against folding-defective NPC1/NPC1L1 mutants
(The 14th Meeting of the Japan Transporter Research Association 2019)
Squalene as a new feedback factor of squalene epoxidase stability
(60th International Conference on the Bioscienceof Lipids (ICBL) 2019)
Chemical biology approach to understand small molecule-mediated degradation of HMG-CoA reductase
(60th International Conference on the Bioscience of Lipids 2019)
Direct alkyne enrichment with silver-immobilized solid supports
(The 14th Annual Meeting of Japanese Society for Chemical Biology 2019)
イトラコナゾールのNPC1に対するシャペロン作用に着目した構造活性相関研究
(メディシナルケミストリーシンポジウム講演要旨集 2018)

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Works (3)：

Simultaneous fitting of sigmoid curves in Excel (Excel Solver Add-in) / protocols.io
Kenji Ohgane 2019 -
Sigmoid fitting in Excel (Excel Solver Add-In) / protocols.io
Kenji Ohgane 2019 -
Quantification of Gel Bands by an Image J Macro, Band/Peak Quantification Tool / protocols.io
Kenji Ohgane, Hiromasa Yoshioka 2019 -

Education (3)：

2008 - 2013 The University of Tokyo
2004 - 2008 The University of Tokyo
2001 - 2004 Sagamihara Senior High School

Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (9)：

2021/04 - 現在 Ochanomizu University Department of Chemistry Assistant Professor (full-time Lecturer)
2020/04 - 2021/03 Tokyo University of Science Department of Applied Biological Science, Faculty of Science and Technology Assistant Professor
2017/10 - 2021/03 Ochanomizu University Department of Chemistry Part-time Lecturer
2018/04 - 2020/03 Institute for Quantitative Biosciences, the University of Tokyo Laboratory of Bioorganic Chemistry Assistant Professor
2017/02 - 2018/03 Institute for Molecular and Cellular Biosciences, the University of Tokyo Laboratory of Bioorganic Chemistry Assistant Professor

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