Rchr
J-GLOBAL ID：201901020086443879
Update date: Apr. 17, 2024
Hirose Hisaaki
Hirose Hisaaki
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Research field (2)：
Molecular biochemistry
, Pharmaceuticals - chemistry and drug development
Research keywords (5)：
細胞内送達
, イメージング
, ペプチド化学
, 細胞外小胞
, エンドサイトーシス
Research theme for competitive and other funds (4)：
2022 - 2025 細胞外小胞の内在化と内包物放出を促進させるペプチドの探索
2023 - 2024 Caイオンを基軸とした、がん細胞の栄養取り込み機構の分子基盤
2023 - 2024 細胞内抗体送達ペプチドの細胞選択性機序解明
2020 - 2022 Visualization of membrane fusion between exosomes and recipient cells
Papers (46)：
Shunsuke Yoshie, Masashi Kuriyama, Masashi Maekawa, Wei Xu, Takuro Niidome, Shiroh Futaki, Hisaaki Hirose. ATP2B4 is an essential gene for epidermal growth factor-induced macropinocytosis in A431 cells. Genes to Cells. 2024
Yusuke Hirai, Yoshimasa Kawaguchi, Chisato Kasahara, Hisaaki Hirose, Shiroh Futaki. Liquid Droplet-Mediated Formulation of Lipid Nanoparticles Encapsulating Immunoglobulin G for Cytosolic Delivery. Molecular Pharmaceutics. 2024
Yoshimasa Kawaguchi, Yuki Kawamura, Hisaaki Hirose, Megumi Kiyokawa, Momo Hirate, Tsuyoshi Hirata, Yuriko Higuchi, Shiroh Futaki. E3MPH16: An efficient endosomolytic peptide for intracellular protein delivery. Journal of controlled release : official journal of the Controlled Release Society. 2024
Wenting Huo, Koji Miki, Huiying Mu, Takashi Osawa, Harumi Yamaguma, Yuuya Kasahara, Satoshi Obika, Yoshimasa Kawaguchi, Hisaaki Hirose, Shiroh Futaki, et al. Light-controllable cell-membrane disturbance for intracellular delivery. Journal of Materials Chemistry B. 2024
Mika Omura, Kenta Morimoto, Yurina Araki, Hisaaki Hirose, Yoshimasa Kawaguchi, Yukiya Kitayama, Yuto Goto, Atsushi Harada, Ikuo Fujii, Tomoka Takatani-Nakase, et al. Inkjet-Based Intracellular Delivery System that Effectively Utilizes Cell-Penetrating Peptides for Cytosolic Introduction of Biomacromolecules through the Cell Membrane. ACS Applied Materials & Interfaces. 2023
ｍore...
Lectures and oral presentations (2)：
高分子細胞内送達ペプチドの設計と送達機序
(日本薬剤学会第38年会 2023)
細胞外物質の細胞内移行様式
(慶應薬学先端実学(サイヤンス)セミナー 2022)
Education (3)：
2009 - 2012 Kyoto University Graduate School of Pharmaceutical Sciences Division of Life Sciences
2007 - 2009 Kyoto University Graduate School of Pharmaceutical Sciences
2003 - 2007 Kyoto University Faculty of Pharmaceutical Sciences
Professional career (1)：
Ph. D (Kyoto University)
Work history (4)：
2019/02 - 2024/03 Kyoto University Institute for Chemical Research
2015/04 - 2019/01 The University of Tokyo Graduate School of Science
2012/06 - 2015/03 Institute de Pharmacologie Moleculaire et Cellulaire, CNRS. Postdoctoral Fellow
2012/04 - 2012/05 Kyoto University Institute for Chemical Research
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