Shimomura Takushi

Affiliation and department：

Research field (2)： Biophysics , Physiology

Research keywords (5)：ナトリウムチャネル , 電位依存性 , two-pore channel , 電気生理学 , イオンチャネル

Research theme for competitive and other funds (6)：

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Papers (19)：

Takushi Shimomura, Kiichi Hirazawa, Yoshihiro Kubo. Conformational rearrangements in the second voltage sensor domain switch PIP2- and voltage-gating modes in two-pore channels. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 6. e2209569120
Daisuke Tsuboi, Takeshi Otsuka, Takushi Shimomura, Md Omar Faruk, Yukie Yamahashi, Mutsuki Amano, Yasuhiro Funahashi, Keisuke Kuroda, Tomoki Nishioka, Kenta Kobayashi, et al. Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior. Cell reports. 2022. 40. 10. 111309-111309
Niklas Brake, Adamo S Mancino, Yuhao Yan, Takushi Shimomura, Yoshihiro Kubo, Anmar Khadra, Derek Bowie. Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific. The Journal of general physiology. 2022. 154. 7
Kiichi Hirazawa, Michihiro Tateyama, Yoshihiro Kubo, Takushi Shimomura. Phosphoinositide regulates dynamic movement of the S4 voltage sensor in the second repeat in two-pore channel 3. The Journal of biological chemistry. 2021. 297. 6. 101425-101425
Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa, et al. Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization. BMC molecular and cell biology. 2021. 22. 1. 3-3

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MISC (6)：

下村拓史, 入江克雅, 入江克雅. Selectivity Determinant of Ancestor-like Prokaryotic Calcium Channel. 生物物理(Web). 2021. 61. 4
下村拓史. サソリ毒の持つ精巧なNa⁺チャネル調節メカニズム. ファルマシア. 2019. 55. 9. 888-888
下村拓史, 今井友也, 名倉仁, 入江克雅, 藤吉好則. 膜電位感受性Na⁺チャネルの電位感受性変異体に見られるセンサードメインの位置変化. 生化学. 2009
Katsumasa Irie, Kazuya Kitagawa, Hitoshi Nagura, Tomoya Imai, Takushi Shimomura, Yoshinori Fujiyoshi. RIGIDITY OF S6 HELIX CONTROLS C-TYPE INACTIVATION RATE OF PROKARYOTIC VOLTAGE-GATED SODIUM CHANNELS. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2009. 59. 250-250
Shimomura Takushi, Nagura Hitoshi, Hige Toshihide, Imai Tomoya, Irie Katsumasa, Mio Kazuhiro, Sato Chikara, Fujiyoshi Yoshinori. 2P289 Large mobility of S4 helix in voltage-gated ion channel revealed by cysteine-scanning(Native and artificial biomembranes,Oral Presentations). Biophysics. 2007. 47. 1. S185

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Books (1)：

Lectures and oral presentations (2)：

Contribution of the 2nd S4 helix for switching PIP2- and voltage-gating modes in two-pore channels
(Ion Channel Modulation Symposium 2023 2023)
膜電位下蛍光電流同時測定法により明らかになった、Two-pore Channelにおけるリガンド依存性と電位依存性ゲーティングの切り替え・統合の分子基盤
(第95回日本生化学会大会 2022)

Education (3)：

2008 - 2011 Kyoto University Graduate School of Science Division of Biological Sciences
2006 - 2008 Kyoto University Graduate School of Science Division of Biological Sciences
2002 - 2006 Kyoto University Faculty of Science

Professional career (1)：

Work history (3)：

2012/04 - 現在 National Institute for Physiological Sciences
2012/04 - 2016/03 Nagoya University Cellular and Structural Physiology Institute
2011/04 - 2012/03 Kyoto University

Awards (2)：

Association Membership(s) (1)：

日本生理学会

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