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J-GLOBAL ID：201901020359411444
Update date: Jan. 30, 2024
Makiko Mochizuki
Makiko Mochizuki
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Affiliation and department：
Tokyo Women's Medical University
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Research field (1)：
Hematology and oncology
Research keywords (3)：
エピジェネティクス
, Hematopoietic stem cell
, Fanconi Anemia
Research theme for competitive and other funds (4)：
2022 - 2027 Analysis of organelle functions for the homeostasis of hematopoietic stem cells and platelet production
2021 - 2024 造血幹細胞におけるRSと細胞内小器官との関連検討によるBMF発症メカニズムの解明
2016 - 2018 Role of H3K36 methyltransferase Mmset in Hematopoietic stem cells
2014 - 2017 ポリコーム群遺伝子Ezh2の造血腫瘍発症におけるメカニズム解析
Papers (24)：
Makiko Mochizuki-Kashio, Noriko Otsuki, Kota Fujiki, Sherif Abdelhamd, Peter Kurre, Markus Grompe, Atsushi Iwama, Kayoko Saito, Ayako Nakamura-Ishizu. Replication stress increases mitochondrial metabolism and mitophagy in FANCD2 deficient fetal liver hematopoietic stem cells. Frontiers in Oncology. 2023. 13
Ayako Nakamura-Ishizu, Desmond Wai Loon Chin, Takayoshi Matsumura, Darren Qiancheng Tan, Makiko Mochizuki-Kashio, Deng Jianwen, Toshio Suda. Prolonged maintenance of hematopoietic stem cells that escape from thrombopoietin deprivation. Blood. 2021. 137. 19. 2609-2620
Makiko Mochizuki-Kashio, Hiroko Shiozaki, Toshio Suda, Ayako Nakamura-Ishizu. Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism. International journal of molecular sciences. 2021. 22. 9
Kazumasa Aoyama, Motohiko Oshima, Shuhei Koide, Emi Suzuki, Makiko Mochizuki-Kashio, Yuko Kato, Shiro Tara, Daisuke Shinoda, Nobuhiro Hiura, Yaeko Nakajima-Takagi, et al. Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome. iScience. 2018. 9. 161-174
Changshan Wang, Motohiko Oshima, Daisuke Sato, Hirotaka Matsui, Sho Kubota, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Shuhei Koide, Jun Matsubayashi, Makiko Mochizuki-Kashio, et al. Ezh2 loss propagates hypermethylation at T cell differentiation-regulating genes to promote leukemic transformation. The Journal of clinical investigation. 2018. 128. 9. 3872-3886
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MISC (11)：
青山 和正, 鈴木 瑛美, 大島 基彦, 望月 牧子, 尾, 小出 周平, 加藤 裕子, 中島 やえ子, 指田 吾郎, 岩間 厚志. Ezh2欠損造血幹細胞維持におけるEzh1によるエピジェネティック制御. 生命科学系学会合同年次大会. 2017. 2017年度. [3PT18-0551)]
Kazumasa Aoyama, Makiko Mochizuki-Kashio, Motohiko Oshima, Shuhei Koide, Yaeko Nakajima-Takagi, Mitsutaka Maeda, Goro Sashida, Atsushi Iwama. Role of the Polycomb Methyltransferase Ezh1 in Myelodysplastic Syndrome Induced By Ezh2 Insufficiency. BLOOD. 2016. 128. 22
青山 和正, 望月 牧子, 尾, 大島 基彦, 小出 周平, 中島 やえ子, 前田 光毅, 指田 吾郎, 岩間 厚志. Ezh2欠損造血細胞におけるEzh1によるエピジェネティック制御. 日本生化学会大会プログラム・講演要旨集. 2016. 89回. [2P-281]
Role of the polycomb-group gene EZH2 in hematopoiesis. 2016. 72. 5. 691-696
青山 和正, 望月 牧子, 尾, 大島 基彦, 小出 周平, 指田 吾郎, 岩間 厚志. ヒストンメチル基転移酵素Ezh2欠損造血幹細胞におけるEzh1の役割. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [1P0601]-[1P0601]
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Professional career (1)：
医科学 (千葉大学)
Association Membership(s) (4)：
THE JAPANESE CANCER ASSOCIATION
, ISEH
, ASH
, THE JAPANESE SOCIETY OF HEMATOLOGY
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