Rchr
J-GLOBAL ID:201901021267241360   Update date: Mar. 19, 2024

Tsukamoto Osamu

Tsukamoto Osamu
Affiliation and department:
Job title: chief professor
Other affiliations (1):
Research field  (2): Cardiology ,  Medical biochemistry
Research keywords  (9): キナーゼ ,  糖・脂肪酸代謝 ,  sarcomere ,  enhancer ,  natriuretic peptides ,  創薬 ,  Biochemistry ,  Heart Failure ,  Caridovascular Medicine
Research theme for competitive and other funds  (18):
  • 2022 - 2025 心臓特異的スーパーエンハンサーの相分離型転写ファクトリーによる転写機構の解明
  • 2020 - 2024 分子疫学的コホート研究による遺伝性心血管疾患のリスク層別化・病態解明・治療薬探索
  • 2019 - 2022 Development of atropine esterase formulation to improve the effect of atropine used in the anesthesiology field
  • 2019 - 2022 Identification of Novel Molecular Targets and Drug Development by Genomic and Multilayer-Omics Analysis of Hereditary Cardiomyopathies
  • 2018 - 2021 Elucidation of the mechanism in which mechanostress modulates cardiac microtubules dynamics
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Papers (68):
  • Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Ken Matsuoka, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Seiji Takashima, Shin Ito, Masafumi Kitakaze. Association Between B-Type Natriuretic Peptide Deficiency and Left Ventricular Concentric Hypertrophy in Subclinical Individuals. JACC: Asia. 2024
  • Osamu Tsukamoto, Seiji Takashima. Response by Tsukamoto and Takashima to Letter Regarding Article, "Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Super-Relaxed Myosin". Circulation. 2023. 148. 25. 2074-2075
  • Hiroshi Kishimoto, Masayoshi Iwasaki, Kensaku Wada, Keita Horitani, Osamu Tsukamoto, Kenta Kamikubo, Seitaro Nomura, Shinji Matsumoto, Takeshi Harada, Daisuke Motooka, et al. Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload. iScience. 2023. 107146-107146
  • Tatsuro Hitsumoto, Osamu Tsukamoto, Ken Matsuoka, Junjun Li, Li Liu, Yuki Kuramoto, Shuichiro Higo, Shou Ogawa, Noboru Fujino, Shohei Yoshida, et al. Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin. Circulation. 2023. 147. 25. 1902-1918
  • Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Tatsuro Hitsumoto, Ken Matsuoka, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Seiji Takashima, Shin Ito, et al. Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical Subjects. Gastro Hep Advances. 2023
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MISC (67):
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Education (2):
  • 2002 - 2006 Osaka University Graduate School of Medicine
  • 1991 - 1997 Miyazaki University
Professional career (1):
  • 医学博士 (大阪大学)
Work history (11):
  • 2023/04 - 現在 Hyogo Medical University Department of Biochemistry chief professor
  • 2023/04 - 現在 Osaka University Graduate School of Medicine visiting professor
  • 2019/07 - 2023/03 大阪大学大学院生命機能研究科・医学系研究科 医化学講座 准教授
  • 2013/09 - 2019/06 大阪大学大学院医学系研究科 医化学講座 助教
  • 2010/04 - 2013/08 大阪大学大学院医学系研究科 分子心血管医学講座 特任研究員
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Committee career (3):
  • 2018 - 現在 Circulation Journal Reports Editorial board
  • 2017 - 現在 American Journal of Physiology-Heart and Circulatory Physiology Editorial board
  • 2015 - 現在 Internaltional Heart Journal Associate editor
Awards (13):
  • 2018 - Best Reviewer of the Year 2018 Japanese Circulation Society
  • 2017 - Best Reviewer of the Year 2017 Japanese Circulation Society
  • 2017 - 大阪大学 先導的学際研究機構創薬サイエンス部門研究助成
  • 2016 - Japanese Circulation Society Japanese Circulation Society
  • 2016 - 公益財団法人先進医薬研究振興財団 公益財団法人先進医薬研究振興財団医化学研究助成
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Association Membership(s) (5):
日本生化学学会 ,  日本分子生物学会 ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  JAPANESE HEART FAILURE SOCIETY ,  The Japanese Circulation Society
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