2019 - 2022 Development of atropine esterase formulation to improve the effect of atropine used in the anesthesiology field
2019 - 2022 Identification of Novel Molecular Targets and Drug Development by Genomic and Multilayer-Omics Analysis of Hereditary Cardiomyopathies
2018 - 2021 Elucidation of the mechanism in which mechanostress modulates cardiac microtubules dynamics
2018 - 2021 Development and clinical application of low molecular chemicals that modulate myosin light chain kinase for the treatment of heart failure with preserved ejection fraction
2017 - 2020 Analysis of the regulatory mechanism of the activity of cardiac specific myosin light chain kinase
2015 - 2018 Elucidation of the irreversible mechanism of severe heart failure using biological monitoring murine heart failure model
2015 - 2018 A novel AMPK singaling at the intercalated disc in heart
2015 - 2018 Elucidation of the regulatory mechanism of natriuretic hormone expression for oral heart failure drug development
2014 - 2017 anti-atherosclerotic and anti-cancer effects of AMPK activation
2013 - 2016 Exploration for Aggravating Process of Heart Failure Induced by Specific Interaction with G-protein-coupled Receptor and Toll-like Receptor
2014 - 2015 Development of simple and noninvasive method to assess the severity of heart failure
2012 - 2015 A New Diagnostics Method for Refractory Heart Failure
2012 - 2015 Role of ER oxidoreductin-1 in cardiovascular remodeling
2010 - 2011 Identification of cardiomyocyte-specific transcriptional mechanism of c-myc
2008 - 2010 Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular Disease
2005 - 2006 心不全の病態における小胞体ストレス誘導性心筋細胞アポトーシスの重要性
Show all
Papers (70):
Shinji Tokuyama, Hisakazu Kato, Hidekazu Takahashi, Kyoko Ueda, Asami Arita, Ryuta Ueda, Hiroto Seto, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, et al. BRAF V600E-induced distinct DNA damage response defines the therapeutic potential of p53 activation for TP53 wild-type colorectal cancer. Carcinogenesis. 2024
Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Ken Matsuoka, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Seiji Takashima, Shin Ito, Masafumi Kitakaze. Relative B-Type Natriuretic Peptide Deficiency May Exist in Diastolic Dysfunction in Subclinical Population. Circulation Reports. 2024. 6. 5. 151-160
Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Ken Matsuoka, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Seiji Takashima, Shin Ito, Masafumi Kitakaze. Association Between B-Type Natriuretic Peptide Deficiency and Left Ventricular Concentric Hypertrophy in Subclinical Individuals. JACC: Asia. 2024
Osamu Tsukamoto, Seiji Takashima. Response by Tsukamoto and Takashima to Letter Regarding Article, "Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Super-Relaxed Myosin". Circulation. 2023. 148. 25. 2074-2075
Hiroshi Kishimoto, Masayoshi Iwasaki, Kensaku Wada, Keita Horitani, Osamu Tsukamoto, Kenta Kamikubo, Seitaro Nomura, Shinji Matsumoto, Takeshi Harada, Daisuke Motooka, et al. Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload. iScience. 2023. 107146-107146
井上聖, 松岡研, JO Hyejin, 塚本蔵, 高島成二, 高島成二. Transcriptional regulation of the natriuretic peptide gene during fetal life and heart failure. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
JO Hyejin, 松岡研, 井上聖, 塚本蔵, 塚本蔵, 塚本蔵, 高島成二, 高島成二. Transcription environment imaging of newly identified cardiac-specific enhancer for regulating transcription of natriuretic peptide genes (Nppa, Nppb). 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th