Research field (4):
Molecular biology
, Psychiatry
, Neuroanatomy and physiology
, Medical biochemistry
Research keywords (7):
synapse
, synaptome
, postsynaptic density
, dendritic spine
, neuroscience
, proteomics
, autophagy
Research theme for competitive and other funds (5):
2022 - 2024 Understanding the nanoscale synaptome architecture of the brain
2018 - 2022 発達過程におけるPSD構成因子の変化とシナプス構築の関係
2020 - 2021 脳全域におけるシナプスの微細分子構造の解析
2016 - 2019 樹状突起スパインの刈り込みにおけるオートファジーの役割の解析
2011 - 2014 哺乳類オートファジーの制御機構の解析
Papers (20):
Takeshi Kaizuka, Toru Takumi. Alteration of synaptic protein composition during developmental synapse maturation. The European journal of neuroscience. 2024
Takeshi Kaizuka, Takehiro Suzuki, Noriyuki Kishi, Kota Tamada, Manfred W. Kilimann, Takehiko Ueyama, Masahiko Watanabe, Tomomi Shimogori, Hideyuki Okano, Naoshi Dohmae, et al. Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development. Nature Communications. 2024. 15. 1
Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O. Collins, Seth G. N. Grant, Yasunori Hayashi, Toru Takumi. FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation. PLOS Biology. 2024. 22. 3. e3002006-e3002006
Fabio de Moliner, Zuzanna Konieczna, Lorena Mendive-Tapia, Rebecca S. Saleeb, Katie Morris, Juan Antonio Gonzalez-Vera, Takeshi Kaizuka, Seth G. N. Grant, Mathew H. Horrocks, Marc Vendrell. Small Fluorogenic Amino Acids for Peptide-Guided Background-Free Imaging. Angewandte Chemie International Edition. 2023
Fabio de Moliner, Zuzanna Konieczna, Lorena Mendive-Tapia, Rebecca S. Saleeb, Katie Morris, Juan Antonio Gonzalez-Vera, Takeshi Kaizuka, Seth G. N. Grant, Mathew H. Horrocks, Marc Vendrell. Small Fluorogenic Amino Acids for Peptide-Guided Background-Free Imaging. Angewandte Chemie. 2023
Diversity of the synaptic nanoarchitecture: Packaging of protein supercomplexes at the postsynaptic density
(2024)
Postsynaptic proteome analysis for understanding of developmental synapse maturation and identification of major postsynaptic molecules
(NEURO2024 2024)
FRET analysis of synaptic nanoarchitecture on a whole-brain scale in mice reveals synapse diversity of PSD95 complex organisation
(SfN Neuroscience 2023 2023)
Analysis of synaptic nanoarchitecture using FRET at the level of single protein complexes and at the whole mouse brain scale
(FENS Forum 2022 2022)