Rchr
J-GLOBAL ID：201901021390931088   Update date: Nov. 26, 2024

Kaizuka Takeshi

カイヅカ タケシ | Kaizuka Takeshi
Affiliation and department：
The University of Edinburgh Centre for Clinical Brain Sciences

About The University of Edinburgh Centre for Clinical Brain Sciences


Job title： Research Fellow
Homepage URL  (1)： https://twitter.com/TakeshiKaizuka
Research field  (4)： Molecular biology ,  Psychiatry ,  Neuroanatomy and physiology ,  Medical biochemistry
Research keywords  (8)： PSD (postsynaptic density) ,  synapse ,  synaptome ,  postsynaptic density ,  dendritic spine ,  neuroscience ,  proteomics ,  autophagy
Research theme for competitive and other funds  (5)：
  • 2022 - 2024 Understanding the nanoscale synaptome architecture of the brain
  • 2018 - 2022 発達過程におけるPSD構成因子の変化とシナプス構築の関係
  • 2020 - 2021 脳全域におけるシナプスの微細分子構造の解析
  • 2016 - 2019 樹状突起スパインの刈り込みにおけるオートファジーの役割の解析
  • 2011 - 2014 哺乳類オートファジーの制御機構の解析
Papers (17)：
  • Katie Morris, Edita Bulovaite, Takeshi Kaizuka, Sebastian Schnorrenberg, Candace T Adams, Noboru Komiyama, Lorena Mendive-Tapia, Seth GN Grant, Mathew H Horrocks. Sequential replacement of PSD95 subunits in postsynaptic supercomplexes is slowest in the cortex. eLife. 2024. 13
  • Sam Daly, Edita Bulovaite, Anoushka Handa, Katie Morris, Leila Muresan, Candace Adams, Takeshi Kaizuka, Alexandre Kitching, Alexander Spark, Gregory Chant, et al. 3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain. bioRxiv. 2024
  • Takeshi Kaizuka, Toru Takumi. Alteration of synaptic protein composition during developmental synapse maturation. The European journal of neuroscience. 2024
  • Takeshi Kaizuka, Takehiro Suzuki, Noriyuki Kishi, Kota Tamada, Manfred W. Kilimann, Takehiko Ueyama, Masahiko Watanabe, Tomomi Shimogori, Hideyuki Okano, Naoshi Dohmae, et al. Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development. Nature Communications. 2024. 15. 1
  • Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O. Collins, Seth G. N. Grant, Yasunori Hayashi, Toru Takumi. FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation. PLOS Biology. 2024. 22. 3. e3002006-e3002006
ｍore...
MISC (11)：
  • 貝塚 剛志, 鈴木 健裕, 岸 憲幸, 岡野 栄之, 堂前 直, 内匠 透. 発達期におけるシナプス後肥厚のリモデリング. 日本生化学会大会プログラム・講演要旨集. 2020. 93回. [1Z12-617)]
  • 吉田 智史, 貝塚 剛志, 内匠 透, 高橋 健造. 新規シナプスタンパク質Aの解析. 琉球医学会誌. 2020. 39. 1-4. 90-90
  • 貝塚 剛志, 鈴木 健裕, 堂前 直, 内匠 透. 発達期におけるシナプス後肥厚のリモデリング. 電気泳動. 2019. 63. Suppl. 244-244
  • 貝塚 剛志. オートファジーの定量的解析. 実験医学. 2017. 35. 15. 2491-2499
  • Hideaki Morishita, Takeshi Kaizuka, Yutaro Hama, Noboru Mizushima. A new probe to measure autophagic flux in vitro and in vivo. AUTOPHAGY. 2017. 13. 4. 757-758
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Patents (2)：
  • オートファジー阻害剤
  • オートファジー誘導剤
Books (1)：
  • 脳内環境辞典
    メディカル ドゥ 2017
Lectures and oral presentations  (10)：
  • Diversity of the synaptic nanoarchitecture: Packaging of protein supercomplexes at the postsynaptic density
    (2024)
  • Postsynaptic proteome analysis for understanding of developmental synapse maturation and identification of major postsynaptic molecules
    (NEURO2024 2024)
  • FRET analysis of synaptic nanoarchitecture on a whole-brain scale in mice reveals synapse diversity of PSD95 complex organisation
    (SfN Neuroscience 2023 2023)
  • Analysis of synaptic nanoarchitecture using FRET at the level of single protein complexes and at the whole mouse brain scale
    (FENS Forum 2022 2022)
  • 発達期の脳におけるシナプス後肥厚のリモデリング
    (次世代脳プロジェクト 冬のシンポジウム2019 2019)
ｍore...
Education (3)：
  • 2010 - 2014 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
  • 2004 - 2008 Tokyo University of Pharmacy and Life Sciences The School of Life Sciences School of Life Science
  • 2001 - 2004 Kanagawa Prefectural Shonan High School General Education Program
Professional career (1)：
  • Ph.D in Medical Science (Tokyo Medical and Dental University)
Work history (7)：
  • 2021/07 - 現在 The University of Edinburgh Centre for Clinical Brain Sciences Research Fellow
  • 2020/04 - 2021/06 Kobe University Graduate School of Medicine Project Assistant Professor
  • 2019/04 - 2020/03 RIKEN Center for Brain Science (CBS) Research Scientist
  • 2016/04 - 2019/03 RIKEN Brain Science Institute (BSI) Visiting Scientist
  • 2016/04 - 2019/03 Japan Society for the Promotion of Science Research Fellow (PD)
Show all
Committee career (1)：
  • 2022/07 - 現在 Frontiers in Neuroscience Review Editor
Awards (5)：
  • 2024 - Japan Association for International Chemical Information JAICI Award
  • 2024 - The Japanese Biochemical Society Encouragement Award
  • 2015/11 - 第9回オートファジー研究会 若手ベストポスター賞
  • 2015/08 - 第27回高遠分子細胞生物学シンポジウム 優秀ポスター賞
  • 2013/08 - 第25回高遠分子細胞生物学シンポジウム 優秀ポスター賞
Association Membership(s) (4)：
The Japan Neuroscience Society ,  Society for Neuroscience ,  Japanese Proteomics Society ,  THE JAPANESE BIOCHEMICAL SOCIETY
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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