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J-GLOBAL ID：201902210251183411   Reference number：19A1048957

Dual Targeting of Bile Acid Receptor-1 (TGR5) and Farnesoid X Receptor (FXR) Prevents Estrogen-Dependent Bone Loss in Mice

胆汁酸受容体1(TGR5)とファルネソイドX受容体(FXR)の二重標的化はマウスにおけるエストロゲン依存性骨損失を予防する【JST・京大機械翻訳】

Author (26)： Li Zhenxi (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China) ,  Li Zhenxi (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Huang Jinping (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Wang Fanhua (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Li Wenjun (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Wu Xian (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Zhao Chenglong (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China) ,  Zhao Chenglong (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Zhao Jian (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China) ,  Zhao Jian (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Wei Haifeng (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China) ,  Wei Haifeng (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Wu Zhipeng (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China) ,  Wu Zhipeng (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Qian Ming (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China) ,  Qian Ming (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Sun Peng (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  He Liang (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Jin Yunyun (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Tang Jie (Institute of Medicinal Chemistry and Department of Chemistry, East China Normal University, Shanghai, China) ,  Qiu Wenwei (Institute of Medicinal Chemistry and Department of Chemistry, East China Normal University, Shanghai, China) ,  Siwko Stefan (Alkek Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX, USA) ,  Liu Mingyao (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Liu Mingyao (Alkek Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX, USA) ,  Luo Jian (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China) ,  Xiao Jianru (East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China)
Material： Journal of Bone and Mineral Research  (JBMR)
Volume： 34  Issue： 4  Page： 765-776  Publication year： 2019 
JST Material Number： W1633A  ISSN： 0884-0431  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Osteoporosis is a global bone ...

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Thesaurus term： *mouse(animal) ,  bone density ,  ovariectomy ,  pathophysiology ,  metabolic pathway ,  osteoblast ,  osteoporosis ,  woman ,  human(primates) ,  bone metabolism ,  osteoclast ,  membrane receptor
Semi thesaurus term： 骨細胞 ,  アゴニスト ,  C57BL/6Jマウス ,  *TGR5 , 【Automatic Indexing@JST】

Author keywords (7)： TGR5 ,  FXR ,  BETULINIC ACID DERIVATIVES ,  AMPK ,  OSTEOPOROSIS ,  OSTEOCLAST ,  OSTEOBLAST

JST classification (3)： Cell physiology in general  (EF02010S) ,  Basic medicine on musculoskeletal system  (GG01020B) ,  Skeletal system  (EJ10030R)

Terms in the title (11)： 胆汁 ,  酸受容体 ,  TGR5 ,  ファルネソイドX受容体 ,  FXR ,  二重標的化 ,  マウス ,  エストロゲン ,  依存性 ,  骨損失 ,  予防