Art

J-GLOBAL ID：201902210590379202   Reference number：19A0068959

Stabilization of P/CAF, as a ubiquitin ligase toward MDM2, suppresses mitotic cell death through p53-p21 activation in HCT116 cells with SIRT2 suppression

Mdm2に対するユビキチンリガーゼとしてのP/CAFの安定化はSIRT2抑制を伴うHCT116細胞におけるp53-p21活性化を介して有糸分裂細胞死を抑制する【JST・京大機械翻訳】

Author (4)： Li Yanze (Division of Human Genome Science, School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, Tottori, 683-8503, Japan) ,  Li Yanze (Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China) ,  Kokura Kenji (Division of Human Genome Science, School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, Tottori, 683-8503, Japan) ,  Inoue Toshiaki (Division of Human Genome Science, School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, Tottori, 683-8503, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 508  Issue： 1  Page： 230-236  Publication year： 2019 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： We previously reported that th...

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Thesaurus term： effectiveness ,  *p53 protein ,  *Mitosis ,  Acetylation ,  Proteins ,  HeLa cell ,  Apoptosis ,  spindle (cytology) ,  interaction ,  Histone Acetyltransferases ,  *p21 ,  *HCT 116 cell ,  *mdm2 protein ,  nitrogen heterocyclic compound ,  aromatic ketone ,  carbamate ,  sulfur heterocyclic compound ,  polynuclear aromatic compound
Semi thesaurus term： 癌治療 , 【Automatic Indexing@JST】

Author keywords (6)： SIRT2 ,  P/CAF ,  MDM2 ,  p53 ,  p21 ,  Mitotic cell death

JST classification (2)： Function of cell components  (EF03060C) ,  Cell division and proliferation  (EF02020D)

Substance index (1)： Nocodazole

Terms in the title (11)： MDM2 ,  ユビキチンリガーゼ ,  CAF ,  安定化 ,  SIRT2 ,  HCT116細胞 ,  p53 ,  p21 ,  活性化 ,  有糸分裂 ,  細胞死