Art

J-GLOBAL ID：201902211204178729   Reference number：19A1280304

Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1β in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis

内皮ミクロソームプロスタグランジンEシンテターゼ-1は実験的自己免疫性脳脊髄炎の悪化進行において血管性と内皮インターロイキン-1βをアップレギュレートする【JST・京大機械翻訳】

Author (3)： Takemiya Takako (Medical Research Institute, Tokyo Women’s Medical University, Tokyo 162-8666, Japan) ,  Kawakami Marumi (Medical Research Institute, Tokyo Women’s Medical University, Tokyo 162-8666, Japan) ,  Takeuchi Chisen (Department of Neurology, Tokyo Metropolitan Kita Medical and Rehabilitation Center for the Disabled, Tokyo 114-0033, Japan)
Material： International Journal of Molecular Sciences (Web)  (Int J Mol Sci (Web))
Volume： 19  Issue： 11  Page： 3647  Publication year： 2018 
JST Material Number： U7038A  ISSN： 1422-0067  CODEN： IJMCFK  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Microsomal prostaglandin E syn...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A1280304&from=J-GLOBAL&jstjournalNo=U7038A") }}

Thesaurus term： *interleukin 1 ,  Multiple Sclerosis ,  *Endothelium ,  Inflammation ,  *Spinal Cord ,  wild type ,  image processing ,  receptor ,  *synthase ,  *blood vessel ,  *microsome ,  Mus musculus ,  prostanoid ,  mPGES-1 ,  *Prostaglandins E ,  Myomorpha

Author keywords (6)： vascular endothelial cells ,  microsomal prostaglandin E synthetase-1 ,  interleukin-1β ,  prostaglandin E₂ ,  experimental autoimmune encephalomyelitis ,  multiple sclerosis

JST classification (1)： Basic neurology  (GN01020W)

Reference (62)：

• Yamagata, K.; Matsumura, K.; Inoue, W.; Shiraki, T.; Suzuki, K.; Yasuda, S.; Sugiura, H.; Cao, C.; Watanabe, Y.; Kobayashi, S. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J. Neurosci. 2001, 21, 2669-2677.
• Takemiya, T.; Matsumura, K.; Sugiura, H.; Maehara, M.; Yasuda, S.; Uematsu, S.; Akira, S.; Yamagata, K. Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate. J. Neurosci. Res. 2010, 88, 381-390.
• Rose, J.W.; Hill, K.E.; Watt, H.E.; Carlson, N.G. Inflammatory cell expression of cyclooxygenase-2 in the multiple sclerosis lesion. J. Neuroimmunol. 2004, 149, 40-49.
• Deininger, M.H.; Schluesener, H.J. Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. J. Neuroimmunol. 1999, 95, 202-208.
• Mendel, I.; Kerlero de Rosbo, N.; Ben-Nun, A. A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: Fine specificity and T cell receptor Vβ expression of encephalitogenic T cells. Eur. J. Immunol. 1995, 25, 1951-1959.

Terms in the title (8)： 内皮 ,  ミクロソーム ,  プロスタグランジンE ,  シンテターゼ ,  実験的自己免疫性脳脊髄炎 ,  悪化 ,  血管 ,  インターロイキン-1β