Art

J-GLOBAL ID：201902211366362527   Reference number：19A2363132

Characterization of Antibody Products Obtained through Enzymatic and Nonenzymatic Glycosylation Reactions with a Glycan Oxazoline and Preparation of a Homogeneous Antibody-Drug Conjugate via Fc N-Glycan

グリカンオキサゾリンとの酵素的および非酵素的グリコシル化反応により得られた抗体生成物の特性化およびFc N-グリカンを介した均一抗体-薬物複合体の調製【JST・京大機械翻訳】

Author (14)： Manabe Shino (Synthetic Cellular Chemistry Laboratory, RIKEN, Saitama, Japan) ,  Yamaguchi Yoshiki (Synthetic Cellular Chemistry Laboratory, RIKEN, Saitama, Japan) ,  Yamaguchi Yoshiki (Structural Glycobiology Team, RIKEN, Saitama, Japan) ,  Matsumoto Kana (Structural Glycobiology Team, RIKEN, Saitama, Japan) ,  Fuchigami Hirobumi (Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Chiba, Japan) ,  Kawase Taiji (Nihon Waters KK, Kitashinagawa, Shinagawa, Japan) ,  Hirose Kenji (Nihon Waters KK, Kitashinagawa, Shinagawa, Japan) ,  Mitani Ai (Fushimi Pharmaceutical Co. Ltd., Nakatsu, Kagawa, Japan) ,  Sumiyoshi Wataru (Fushimi Pharmaceutical Co. Ltd., Nakatsu, Kagawa, Japan) ,  Kinoshita Takashi (Fushimi Pharmaceutical Co. Ltd., Nakatsu, Kagawa, Japan) ,  Abe Junpei (Synthetic Cellular Chemistry Laboratory, RIKEN, Saitama, Japan) ,  Yasunaga Masahiro (Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Chiba, Japan) ,  Matsumura Yasuhiro (Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Chiba, Japan) ,  Ito Yukishige (Synthetic Cellular Chemistry Laboratory, RIKEN, Saitama, Japan)
Material： Bioconjugate Chemistry  (Bioconj Chem)
Volume： 30  Issue： 5  Page： 1343-1355  Publication year： 2019 
JST Material Number： W0169A  ISSN： 1043-1802  CODEN： BCCHES  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Glycan engineering of antibodi...

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Thesaurus term： *enzyme ,  amino group ,  *antibody formation ,  cytotoxicity ,  side reaction ,  optimum condition ,  orthogonality ,  *characterization ,  *complex(substance) ,  *antibody ,  *glycosylation ,  azide(organic) ,  tandem mass spectrometry
Semi thesaurus term： リモデリング ,  *グリカン , 【Automatic Indexing@JST】

JST classification (4)： Proteins and peptides in general  (EB03010N) ,  Coordination compounds in general  (CE01010G) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Antigens,antibodies,complements in general  (ED04010A)

Terms in the title (7)： 酵素 ,  グリコシル化反応 ,  抗体生成 ,  特性化 ,  N-グリカン ,  抗体-薬物複合体 ,  調製