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J-GLOBAL ID：201902211474030225   Reference number：19A0610833

Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice

内因性HMGB2の消失はマウスにおける心機能障害と圧過負荷誘発心不全を促進する

Author (24)： Sato Michio (Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University) ,  Sato Michio (Department of Cardiovascular Medicine, Saga University) ,  Miyata Keishi (Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University) ,  Miyata Keishi (Department of Immunology, Allergy and Vascular Medicine, Graduate School of Medical Sciences, Kumamoto University) ,  Tian Zhe (Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University) ,  Kadomatsu Tsuyoshi (Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University) ,  Ujihara Yoshihiro (First Department of Physiology, Kawasaki Medical School) ,  Morinaga Jun (Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University) ,  Horiguchi Haruki (Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University) ,  Endo Motoyoshi (Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University) ,  Zhao Jiabin (Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University) ,  Zhu Shunshun (Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University) ,  Sugizaki Taichi (Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University) ,  Igata Kimihiro (Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University) ,  Muramatsu Masashi (Division of Molecular and Vascular Biology, Institute of Resource Development and Analysis, Kumamoto University) ,  Minami Takashi (Division of Molecular and Vascular Biology, Institute of Resource Development and Analysis, Kumamoto University) ,  Ito Takashi (Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Science) ,  Bianchi Marco E (Chromatin Dynamics Unit, San Raffaele University and Scientific Institute) ,  Mohri Satoshi (First Department of Physiology, Kawasaki Medical School) ,  Araki Kimi (Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University) ,  Araki Kimi (Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University) ,  Node Koichi (Department of Cardiovascular Medicine, Saga University) ,  Oike Yuichi (Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University) ,  Oike Yuichi (Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto University)
Material： Circulation Journal  (Circ J)
Volume： 83  Issue： 2  Page： 368-378(J-STAGE)  Publication year： 2019 
JST Material Number： F0908A  ISSN： 1346-9843  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *HMG protein ,...
Semi thesaurus term： *HMGB2 ,...

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Author keywords (4)： Aging ,  Heart failure ,  HMGB2 ,  Transverse aorta constriction (TAC) model

JST classification (1)： Basic medicine on cardiovascular system  (GJ01020K)

Reference (28)：

• 1. Lloyd-Jones DM, Larson MG, Leip EP, Beiser A, D’Agostino RB, Kannel WB, et al. Lifetime risk for developing congestive heart failure: The Framingham Heart Study. Circulation 2002; 106: 3068-3072.
• 2. Ambrosy AP, Fonarow GC, Butler J, Chioncel O, Greene SJ, Vaduganathan M, et al. The global health and economic burden of hospitalizations for heart failure: Lessons learned from hospitalized heart failure registries. J Am Coll Cardiol 2014; 63: 1123-1133.
• 3. Okura Y, Ramadan MM, Ohno Y, Mitsuma W, Tanaka K, Ito M, et al. Impending epidemic: Future projection of heart failure in Japan to the year 2055. Circ J 2008; 72: 489-491.
• 4. Sakata Y, Shimokawa H. Epidemiology of heart failure in Asia. Circ J 2013; 77: 2209-2217.
• 5. Berry JD, Dyer A, Cai X, Garside DB, Ning H, Thomas A, et al. Lifetime risks of cardiovascular disease. N Engl J Med 2012; 366: 321-329.

Terms in the title (8)： 内因性 ,  マウス ,  心機能障害 ,  圧 ,  過負荷 ,  誘発 ,  心不全 ,  促進