Art

J-GLOBAL ID：201902211947951773   Reference number：19A1968105

Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists

ヒトペルオキシソーム増殖因子活性化受容体アルファ(PPARα)選択的アゴニストとしての1H-ピラゾロ[3,4-b]ピリジン-4-カルボン酸誘導体の構造発達【JST・京大機械翻訳】

Author (10)： Miyachi Hiroyuki (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan) ,  Yuzuriha Tomohiro (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Tabata Ryotaro (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Fukuda Syohei (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Nunomura Kazuto (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Lin Bangzhong (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Kobayashi Tadayuki (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Ishimoto Kenji (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Doi Takefumi (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Tachibana Keisuke (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 29  Issue： 16  Page： 2124-2128  Publication year： 2019 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： We previously reported that 1H...

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Thesaurus term： fibroblast ,  acidity(property) ,  *human(primates) ,  plasma(blood) ,  hydrophobic ,  structure-activity relationship ,  *PPAR alpha ,  triglyceride ,  alpha adrenergic agonist ,  aromatic ketone ,  aromatic chlorine compound ,  phenol ether ,  carboxylate(ester)
Semi thesaurus term： PPARαアゴニスト ,  置換基 ,  構造活性相関研究 ,  構造進化 ,  *アゴニスト , 【Automatic Indexing@JST】

Author keywords (6)： Peroxisome proliferator-activated receptor alpha ,  PPAR ,  1H-Pyrazolo-[3 4-b]pyridine-4-carboxylic acid ,  Structure-activity relationship ,  Agonist ,  PPARα agonist

JST classification (2)： Synthesis of drugs  (GV01030F) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (1)： Fenofibrate

Terms in the title (7)： ヒト ,  ペルオキシソーム増殖因子活性化受容体 ,  PPARα ,  アゴニスト ,  ピリジン-4-カルボン酸 ,  誘導体 ,  構造発達