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J-GLOBAL ID：201902212065327447   Reference number：19A1103301

Acid Sphingomyelinase Promotes Cellular Internalization of Clostridium perfringens Iota-Toxin

Clostridium perfringens Iota毒素の細胞内インターナリゼーションを促進する酸性スフィンゴomyel【JST・京大機械翻訳】

Author (5)： Nagahama Masahiro (Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan) ,  Takehara Masaya (Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan) ,  Miyamoto Kazuaki (Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan) ,  Ishidoh Kazumi (Division of Molecular Biology, Institute for Health Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan) ,  Kobayashi Keiko (Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan)
Material： Toxins (Web)
Volume： 10  Issue： 5  Page： 209  Publication year： 2018 
JST Material Number： U7286A  ISSN： 2072-6651  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Clostridium perfringens iota-t...

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Thesaurus term： cytotoxicity ,  lysosome ,  Exocytosis ,  complex (substance) ,  *toxin ,  *acidity (property) ,  enzyme ,  siRNA ,  *Clostridium perfringens ,  actin ,  Endocytosis ,  *internalization ,  ceramide ,  membrane receptor ,  lipid raft ,  *microorganism ,  *Spore-Forming Bacteria ,  *Bacillaceae ,  Endomembrane system

Author keywords (3)： C. perfringens iota-toxin ,  membrane repair ,  acid sphingomyelinase

JST classification (2)： Physiology and pathogenicity of microbial infection  (EG03053T) ,  Toxicity of microorganism derived substances  (GZ03030F)

Reference (32)：

• Sakurai, J.; Nagahama, M.; Oda, M.; Tsuge, H.; Kobayashi, K. Clostridium perfringens iota-toxins: Structure and function. Toxins (Basel) 2009, 1, 208-228.
• Aktories, K.; Lang, A.E.; Schwan, C.; Mannherz, H.G. Actin as target for modification by bacterial protein toxins. FEBS J. 2011, 278, 4526-4543.
• Aktories, K.; Schwan, C.; Papatheodorou, P.; Lang, A.E. Bidirectional attack on the actin cytoskeleton. Bacterial protein toxins causing polymerization or depolymerization of actin. Toxicon 2012, 60, 572-581.
• Stiles, B.G.; Pradhan, K.; Fleming, J.M.; Samy, R.P.; Barth, H.; Popoff, M.R. Clostridium and Bacillus binary enterotoxins: Bad for the bowels, and eukaryotic being. Toxins (Basel) 2014, 6, 2626-2656.
• Knapp, O.; Benz, R.; Popoff, M.R. Pore-forming activity of clostridial binary toxins. Biochim. Biophys. Acta 2015, 1858, 512-525.

Terms in the title (5)： Clostridium ,  毒素 ,  インターナリゼーション ,  促進 ,  酸性