Art

J-GLOBAL ID：201902212316245345   Reference number：19A2871971

Homology modeling and site-directed mutagenesis identify amino acid residues underlying the substrate selection mechanism of human monocarboxylate transporters 1 (hMCT1) and 4 (hMCT4)

ホモロジーモデリングと部位特異的変異誘発はヒトモノカルボン酸輸送体1(HMCT1)と4(HMCT4)の基質選択機構の基礎となるアミノ酸残基を同定する【JST・京大機械翻訳】

Author (8)： Futagi Yuya (Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Futagi Yuya (Japan Society for the Promotion of Science (JSPS), Tokyo, Japan) ,  Kobayashi Masaki (Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Kobayashi Masaki (Department of Pharmacy, Hokkaido University Hospital, Sapporo, Japan) ,  Narumi Katsuya (Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Furugen Ayako (Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Iseki Ken (Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Iseki Ken (Department of Pharmacy, Hokkaido University Hospital, Sapporo, Japan)
Material： Cellular and Molecular Life Sciences
Volume： 76  Issue： 24  Page： 4905-4921  Publication year： 2019 
JST Material Number： B0496A  ISSN： 1420-682X  CODEN： CMLSFI  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Human monocarboxylate transpor...

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Thesaurus term： *mutagenesis ,  three dimension ,  *substrate(biochemistry) ,  energy metabolism ,  *human(primates) ,  hydrophobic ,  *amino acid residue ,  conformational transition ,  homology(characteristic) ,  substrate specificity ,  linear structure ,  turnover number ,  cell membrane ,  hydrophobic interaction ,  *site-directed mutagenesis

Author keywords (6)： Monocarboxylate transporter ,  hMCT1 ,  hMCT4 ,  l-Lactic acid ,  l-5-Oxoproline ,  Oocyte

JST classification (2)： Molecular structure  (EB03020Y) ,  Enzyme physiology  (EJ02020P)

Terms in the title (8)： ホモロジーモデリング ,  部位特異的変異誘発 ,  ヒト ,  モノカルボン酸輸送体 ,  基質 ,  基礎 ,  アミノ酸残基 ,  同定