Art

J-GLOBAL ID：201902212462671215   Reference number：19A2083237

Binimetinib, a novel MEK1/2 inhibitor, exerts anti-leukemic effects under inactive status of PI3Kinase/Akt pathway

新規MEK1/2阻害剤ビニメチニブはPI3キナーゼ/Akt経路の不活性状態下で抗白血病効果を発揮する

Author (13)： Sakakibara Kanae (Division of Medical Technology, Kawasaki University of Medical Welfare, Okayama, Japan) ,  Sakakibara Kanae (Field of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama, Japan) ,  Tsujioka Takayuki (Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan) ,  Kida Jun-ichiro (Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan) ,  Kurozumi Nami (Division of Medical Technology, Kawasaki University of Medical Welfare, Okayama, Japan) ,  Kurozumi Nami (Field of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama, Japan) ,  Nakahara Takako (Division of Medical Technology, Kawasaki University of Medical Welfare, Okayama, Japan) ,  Suemori Shin-ichiro (Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan) ,  Kitanaka Akira (Division of Medical Technology, Kawasaki University of Medical Welfare, Okayama, Japan) ,  Kitanaka Akira (Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan) ,  Arao Yujiro (Field of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama, Japan) ,  Tohyama Kaoru (Division of Medical Technology, Kawasaki University of Medical Welfare, Okayama, Japan) ,  Tohyama Kaoru (Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan)
Material： International Journal of Hematology  (Int J Hematol)
Volume： 110  Issue： 2  Page： 213-227  Publication year： Aug. 2019 
JST Material Number： F0888A  ISSN： 0925-5710  CODEN： IJHEEY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： MAP kinase kinase ,...
Semi thesaurus term： MEK1/2 ,...

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Author keywords (4)： Myelodysplastic syndromes (MDS) ,  N-RAS mutation ,  G1 arrest ,  Akt phosphorylation

JST classification (2)： Experimental treatment for tumors  (GE02040Y) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Binimetinib

Terms in the title (8)： MEK1 ,  阻害剤 ,  ビニメチニブ ,  PI3キナーゼ ,  Akt ,  経路 ,  不活性状態 ,  白血病