Art

J-GLOBAL ID：201902212603782720   Reference number：19A1880503

Identification of Morpholino-2H-pyrido[3,2-b][1,4]-oxazin-3(4H)-ones as Nonsteroidal Mineralocorticoid Antagonists

非ステロイド性ミネラルコルチコイドアンタゴニストとしてのモルホリノ-2H-ピリド[3,2-b][1,4]-オキサジン-3(4H)-オン類の同定【JST・京大機械翻訳】

Author (15)： Piotrowski David W. (Pfizer Research and Development, Connecticut, United States) ,  Futatsugi Kentaro (Pfizer Research and Development, Connecticut, United States) ,  Casimiro-Garcia Agustin (Pfizer Research and Development, Connecticut, United States) ,  Wei Liuqing (Pfizer Research and Development, Connecticut, United States) ,  Sammons Matthew F. (Pfizer Research and Development, Connecticut, United States) ,  Herr Michael (Pfizer Research and Development, Connecticut, United States) ,  Jiao Wenhua (Pfizer Research and Development, Connecticut, United States) ,  Lavergne Sophie Y. (Pfizer Research and Development, Connecticut, United States) ,  Coffey Steven B. (Pfizer Research and Development, Connecticut, United States) ,  Wright Stephen W. (Pfizer Research and Development, Connecticut, United States) ,  Song Kun (Pfizer Research and Development, Connecticut, United States) ,  Loria Paula M. (Pfizer Research and Development, Connecticut, United States) ,  Banker Mary Ellen (Pfizer Research and Development, Connecticut, United States) ,  Petersen Donna N. (Pfizer Research and Development, Connecticut, United States) ,  Bauman Jonathan (Pfizer Research and Development, Connecticut, United States)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 61  Issue： 3  Page： 1086-1097  Publication year： 2018 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： A novel series of morpholine-b...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A1880503&from=J-GLOBAL&jstjournalNo=D0102A") }}

Thesaurus term： Safety ,  clearance ,  human ,  effectiveness ,  optimization ,  *Rattus ,  high dosage ,  binding affinity ,  nuclear hormone receptor ,  Mineralocorticoid receptor antagonist ,  modification ,  *Myomorpha
Semi thesaurus term： 機能的能力 , 【Automatic Indexing@JST】

JST classification (2)： Structure-activity relationship of drugs  (GV01050B) ,  Synthesis of drugs  (GV01030F)

Terms in the title (3)： ステロイド ,  オキサジン ,  同定