Art

J-GLOBAL ID：201902212647086507   Reference number：19A1527884

TNF-α-induced Tim-3 expression marks the dysfunction of infiltrating natural killer cells in human esophageal cancer

TNF-α誘導TIM-3発現はヒト食道癌における浸潤ナチュラルキラー細胞の機能障害を示す【JST・京大機械翻訳】

Author (9)： Zheng Yujia (Biotherapy Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China) ,  Li Yu (Biotherapy Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China) ,  Lian Jingyao (Biotherapy Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China) ,  Yang Huiyun (Biotherapy Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China) ,  Li Feng (Biotherapy Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China) ,  Zhao Song (Department of Thoracic Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China) ,  Qi Yu (Department of Thoracic Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China) ,  Zhang Yi (Biotherapy Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China) ,  Huang Lan (Biotherapy Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China)
Material： Journal of Translational Medicine (Web)
Volume： 17  Issue： 1  Page： 165  Publication year： 2019 
JST Material Number： U7330A  ISSN： 1479-5876  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Impairment of natural killer (...

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Thesaurus term： *esophageal tumor ,  *human(primates) ,  *TNF alpha ,  tumor invasion ,  peripheral blood ,  biomarker ,  up-regulation ,  prognosis ,  mRNA ,  T cell ,  donor ,  tumor ,  perforin ,  *NK cell ,  *immersional wetting

Author keywords (5)： Tumor microenvironment ,  NK cells ,  Tim-3 ,  TNF-α ,  Esophageal cancer

JST classification (1)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (44)：

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• Nat Commun; IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours; H Seo, I Jeon, B-S Kim, M Park, E-A Bae, B Song, C-H Koh, K-S Shin, I-K Kim, K Choi; 8; 2017; 15776; 10.1038/ncomms15776; citation_id=CR5

Terms in the title (9)： TNF-α ,  誘導 ,  TIM-3 ,  発現 ,  ヒト ,  食道癌 ,  浸潤 ,  ナチュラルキラー細胞 ,  機能障害