Art

J-GLOBAL ID：201902213143831369   Reference number：19A1968396

Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway

新規神経毒,アンチモンはラパマイシン経路の蛋白質キナーゼB/哺乳類標的の活性酸素種媒介阻害を介してニューロン自食死を引き起こす【JST・京大機械翻訳】

Author (14)： Wang Xiaoke (Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nangtong University, Nantong, 226019, China) ,  Zhu Piaoyu (Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nangtong University, Nantong, 226019, China) ,  Xu Shenya (Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nangtong University, Nantong, 226019, China) ,  Liu Yuting (Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nangtong University, Nantong, 226019, China) ,  Jin Yang (Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nangtong University, Nantong, 226019, China) ,  Yu Shali (Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nangtong University, Nantong, 226019, China) ,  Wei Haiyan (Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nangtong University, Nantong, 226019, China) ,  Li Jinlong (School of Pharmacy, Nantong University, Nantong, 226001, China) ,  Zhang Qinglin (Departments of Gastroenterology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, China) ,  Hasegawa Takahiro (Department of Molecular Oral Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School, 770-8504, Japan) ,  Yao Chenjuan (Department of Molecular Oral Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School, 770-8504, Japan) ,  Yoshimura Hiroshi (Department of Molecular Oral Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School, 770-8504, Japan) ,  Wu Qiyun (Department of Nutrition and Food Hygiene, School of Public Health, Nangtong University, Nantong, 226019, China) ,  Zhao Xinyuan (Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nangtong University, Nantong, 226019, China)
Material： International Journal of Biochemistry & Cell Biology  (International Journal of Biochemistry and Cell Biology)
Volume： 114  Page： Null  Publication year： 2019 
JST Material Number： B0255C  ISSN： 1357-2725  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Antimony (Sb), a naturally occ...

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Thesaurus term： human ,  *Mammalia ,  phosphorylation ,  *neuron ,  *neurotoxin ,  Apoptosis ,  Autophagy ,  light chain ,  *active oxygen ,  in vitro experiment ,  *Antimony ,  TOR Serine-Threonine Kinases ,  p62 ,  LC3 ,  *Vertebrata ,  ether ,  macrocyclic compound ,  lactam ,  lactone ,  enzyme inhibitor ,  hemiacetal ,  alicyclic alcohol ,  secondary alcohol ,  hydroxy ketone

Author keywords (6)： Antimony ,  Neurotoxicity ,  Autophagy ,  Akt/mTOR inhibition ,  Neuronal apoptosis ,  ROS

JST classification (2)： Cell physiology in general  (EF02010S) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Sirolimus

Terms in the title (11)： 神経毒 ,  アンチモン ,  ラパマイシン ,  経路 ,  蛋白質キナーゼB ,  哺乳類 ,  標的 ,  活性酸素種 ,  阻害 ,  ニューロン ,  食