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J-GLOBAL ID：201902213290277128   Reference number：19A2733736

β-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells

アリール炭化水素受容体の外因性リガンド,β-ナフトフラボンはヒト肝細胞癌HepG2細胞における亜鉛ホメオスタシスを破壊する

Author (2)： Ishida Takumi (Faculty of Pharmaceutical Sciences, Sojo University) ,  Takechi Shinji (Faculty of Pharmaceutical Sciences, Sojo University)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 44  Issue： 10  Page： 711-720(J-STAGE)  Publication year： 2019 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： ligand ,...
Semi thesaurus term： mRNA expression ,...

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Author keywords (6)： β-Naphthoflavone ,  Zinc homeostasis ,  Intracellular labile zinc ,  Aryl hydrocarbon receptor ,  HepG2 ,  Zinc transporter

JST classification (3)： Animal metabolism and nutrition in general  (EJ02031R) ,  Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q)

Substance index (2)： β-Naphthoflavone ,  Zinc pyrithione

Reference (85)：

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• Arslanian, M.J., Pascoe, E. and Reinhold, J.G. (1971): Rat liver alcohol dehydrogenase. Purification and properties. Biochem. J., 125, 1039-1047.
• Bafaro, E., Liu, Y., Xu, Y. and Dempski, R.E. (2017): The emerging role of zinc transporters in cellular homeostasis and cancer. Signal Transduct. Target. Ther., 2, e17029.
• Barnett, B.L., Kretschmar, H.C. and Hartman, F.A. (1977): Structural characterization of bis(N-oxopyridine-2-thionato)zinc(II). Inorg. Chem., 16, 1834-1838.
• Berry, A. and Marshall, K.E. (1993): Identification of zinc-binding ligands in the class II fructose-1,6-bisphosphate aldolase of Escherichia coli. FEBS Lett., 318, 11-16.

Terms in the title (9)： アリール炭化水素受容体 ,  リガンド ,  β-ナフトフラボン ,  ヒト ,  肝細胞癌 ,  HepG2細胞 ,  亜鉛 ,  ホメオスタシス ,  破壊