Art

J-GLOBAL ID：201902213328695041   Reference number：19A1827797

Flavanone glycosides inhibit β-site amyloid precursor protein cleaving enzyme 1 and cholinesterase and reduce Aβ aggregation in the amyloidogenic pathway

フラバノングリコシドはβ部位アミロイド前駆体蛋白質切断酵素1とコリンエステラーゼを阻害し,アミロイド形成経路におけるAβ凝集を減少させる【JST・京大機械翻訳】

Author (11)： Ali Md Yousof (Department of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea) ,  Ali Md Yousof (Department of Chemistry and Biochemistry, Faculty of Arts and Science, Concordia University, 7141, Sherbrooke St. W, Montreal, Quebec, Canada) ,  Ali Md Yousof (Department of Biology, Faculty of Arts and Science, Concordia University, 7141, Sherbrooke St. W, Montreal, Quebec, Canada) ,  Ali Md Yousof (Centre for Structural and Functional Genomic, Dept. of Biology, Faculty of Arts and Science, Concordia University, 7141, Sherbrooke St. W, Montreal, QC, Canada) ,  Jannat Susoma (Department of Biochemistry and Molecular Biology, University of Calgary, T2N 1N4, Alberta, Canada) ,  Edraki Najmeh (Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran) ,  Das Sucharita (Department of Microbiology, University of Calcutta, 35 Ballygunge, Kolkata, 700 019, India) ,  Chang Won Kyu (Department of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea) ,  Kim Hyun Chul (Department of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea) ,  Park Seong Kyu (Department of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea) ,  Chang Mun Seog (Department of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea)
Material： Chemico-Biological Interactions  (Chem Biol Interact)
Volume： 309  Page： Null  Publication year： 2019 
JST Material Number： H0058B  ISSN： 0009-2797  CODEN： CBINA  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Alzheimer’s disease (AD) is a ...

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Thesaurus term： Alzheimer disease ,  in vitro experiment ,  flavonoid ,  human(primates) ,  *aggregation ,  docking ,  glycosylation ,  neuron ,  *cholinesterase ,  *amyloid ,  *glycoside ,  acetylcholinesterase ,  amyloid beta-protein ,  aromatic ketone ,  oxygen heterocyclic compound ,  polyphenol ,  polynuclear aromatic compound
Semi thesaurus term： 阻害剤 ,  阻害活性 , 【Automatic Indexing@JST】

Author keywords (6)： Flavonoids ,  Didymin ,  β-amyloid ,  BACE1 ,  Alzheimer’s disease ,  Molecular docking

JST classification (1)： Cell physiology in general  (EF02010S)

Substance index (1)： Naringenin

Terms in the title (7)： アミロイド前駆体蛋白質 ,  酵素 ,  コリンエステラーゼ ,  阻害 ,  アミロイド形成 ,  経路 ,  凝集