Art

J-GLOBAL ID：201902213588858286   Reference number：19A2811981

Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients

日本人高コレステロール血症患者におけるアトルバスタチンの薬物動態学的および薬理遺伝学的特性を明らかにするための微量投与臨床試験

Author (15)： Lee Nora (Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan) ,  Lee Nora (Life Science Research Institute, Daewoong Pharmaceutical, Co., Ltd., 72 Dugye-ro, Pogok-eup, Cheoin-gu, Yongin, 17028, South Korea) ,  Maeda Kazuya (Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 Chome-3-1 Hongo, Bunkyo, Tokyo, 113-0033, Japan) ,  Fukizawa Shinya (Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 Chome-3-1 Hongo, Bunkyo, Tokyo, 113-0033, Japan) ,  Ieiri Ichiro (Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Tomaru Atsuko (Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan) ,  Akao Hironobu (Department of Cardiology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan) ,  Takeda Kenji (Department of Cardiology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan) ,  Iwadare Mizuho (Department of Cardiology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan) ,  Niwa Osamu (Department of Pharmacy, Kanazawa Medical University Hospital, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan) ,  Masauji Tougen (Department of Pharmacy, Kanazawa Medical University Hospital, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan) ,  Yamane Naoe (CMIC Pharma Science Co., Ltd., Hamamatsu-Cho Building, 1-1-1, Shibaura, Minato-ku, Tokyo, 105-0023, Japan) ,  Kajinami Kouji (Department of Cardiology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan) ,  Kusuhara Hiroyuki (Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 Chome-3-1 Hongo, Bunkyo, Tokyo, 113-0033, Japan) ,  Sugiyama Yuichi (Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan)
Material： Drug Metabolism and Pharmacokinetics (Web)  (Drug Metab Pharmacokinet (Web))
Volume： 34  Issue： 6  Page： 387-395  Publication year： 2019 
JST Material Number： U0705A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： microdose clinical study ,...

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Author keywords (6)： Atorvastatin ,  Hypercholesterolemia ,  Microdose ,  Non-linear pharmacokinetics ,  OATP1B1 (SLCO1B1) ,  BCRP (ABCG2)

JST classification (1)： Clinical biopharmacy  (GY01022L)

Substance index (1)： Atorvastatin

Terms in the title (7)： 日本人 ,  高コレステロール血症 ,  患者 ,  アトルバスタチン ,  薬物動態学 ,  薬理遺伝学 ,  微量投与臨床試験