Art

J-GLOBAL ID：201902213785591164   Reference number：19A2277968

Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity

4,6-二置換インダゾール誘導体のインドールアミン-2,3-ジオキシゲナーゼ1阻害活性の相関とそれらのヘム結合親和性【JST・京大機械翻訳】

Author (13)： Tsujino Hirofumi (Laboratory of Analytical Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Uno Tadayuki (Laboratory of Analytical Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Yamashita Taku (Laboratory of Analytical Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Yamashita Taku (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, 11-68 Koshien-Kyubancho, Nishinomiya, Hyogo 663-8179, Japan) ,  Katsuda Masafumi (Laboratory of Analytical Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Takada Kazuki (Laboratory of Analytical Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Saiki Takeshi (Laboratory of Analytical Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Maeda Shotaro (Laboratory of Analytical Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Takagi Akira (Laboratory of Synthetic Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka 1-6, Suita, Osaka 565-0871, Japan) ,  Masuda Shigeaki (Laboratory of Synthetic Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka 1-6, Suita, Osaka 565-0871, Japan) ,  Kawano Yasuhiko (Laboratory of Synthetic Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka 1-6, Suita, Osaka 565-0871, Japan) ,  Meguro Kanji (Compound Library Screening Center, Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka 1-6, Suita, Osaka 565-0871, Japan) ,  Akai Shuji (Laboratory of Synthetic Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka 1-6, Suita, Osaka 565-0871, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 29  Issue： 19  Page： Null  Publication year： 2019 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Indoleamine 2,3-dioxygenase 1 ...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A2277968&from=J-GLOBAL&jstjournalNo=W0248A") }}

Thesaurus term： human(primates) ,  iron ,  *dioxygenase ,  *affinity ,  rate-limiting ,  biological activity ,  interaction ,  absorption spectrum ,  in vitro experiment ,  amino acid ,  nitrogen heterocyclic compound ,  polynuclear aromatic compound ,  primary amine
Semi thesaurus term： 鉄(III) ,  in silico ,  置換基 ,  阻害剤 ,  *結合親和性 ,  *阻害活性 , 【Automatic Indexing@JST】

Author keywords (4)： Heme protein ,  Indoleamine 2 3-dioxygenase 1 inhibitor ,  Structure-based drug design ,  Indazole derivatives

JST classification (1)： Structure-activity relationship of drugs  (GV01050B)

Substance index (1)： Tryptophan

Terms in the title (7)： 置換 ,  インダゾール誘導体 ,  ジオキシゲナーゼ ,  阻害活性 ,  相関 ,  ヘム ,  結合親和性