Art

J-GLOBAL ID：201902213906359319   Reference number：19A0022364

Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer

PAC3ホモ二量体の蛋白質-蛋白質相互作用阻害剤としてのチエルシンB1類似体の合成と生物学的評価【JST・京大機械翻訳】

Author (9)： Ohsawa Kosuke (Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan) ,  Yoshida Masahito (Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan) ,  Izumikawa Miho (Japan Biological Informatics Consortium (JBIC), 2-4-32 Aomi, Koto-ku, Tokyo 135-0064, Japan) ,  Takagi Motoki (Japan Biological Informatics Consortium (JBIC), 2-4-32 Aomi, Koto-ku, Tokyo 135-0064, Japan) ,  Shin-ya Kazuo (National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan) ,  Goshima Naoki (National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan) ,  Hirokawa Takatsugu (National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan) ,  Natsume Tohru (National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan) ,  Doi Takayuki (Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 26  Issue： 23-24  Page： 6023-6034  Publication year： 2018 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The synthesis and biological e...

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Thesaurus term： chaperone protein ,  docking ,  Esterification ,  etherification ,  proteasome ,  *analogical material ,  complex (substance) ,  biological activity ,  hydrophobic interaction ,  methyl group ,  in silico ,  *protein-protein interaction ,  *homodimer ,  phenol ether
Semi thesaurus term： *阻害剤 , 【Automatic Indexing@JST】

Author keywords (4)： Protein-protein interaction inhibitors ,  Protein assembling chaperon 3 (PAC3) ,  Natural product analogues ,  Multi-substituted benzene

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Synthesis of drugs  (GV01030F)

Substance index (1)： Diphenyl ether

Terms in the title (5)： ホモ二量体 ,  蛋白質-蛋白質相互作用 ,  阻害剤 ,  類似体 ,  生物学的評価