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J-GLOBAL ID：201902214974299381   Reference number：19A1287164

An RNA Switch of a Large Exon of Ninein Is Regulated by the Neural Stem Cell Specific-RNA Binding Protein, Qki5

nineの大エキソンのRNAスイッチは神経幹細胞特異的RNA結合蛋白質QKI5により調節される【JST・京大機械翻訳】

Author (2)： Hayakawa-Yano Yoshika (Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, 757, Ichibancho, Asahimachidori, Chuo-ku, Niigata, Niigata 951-8510, Japan) ,  Yano Masato (Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, 757, Ichibancho, Asahimachidori, Chuo-ku, Niigata, Niigata 951-8510, Japan)
Material： International Journal of Molecular Sciences (Web)  (Int J Mol Sci (Web))
Volume： 20  Issue： 5  Page： 1010  Publication year： 2019 
JST Material Number： U7038A  ISSN： 1422-0067  CODEN： IJMCFK  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： A set of tissue-specific splic...

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Thesaurus term： Alternative Splicing ,  *neural stem cell ,  immunoprecipitation ,  gene ,  shake out ,  mRNA ,  cerebral cortex ,  axon ,  *RNA binding protein ,  *switch ,  polypeptide ,  visualization ,  *RNA ,  neuron ,  annotation ,  molecular genetic phenomenon ,  bioassay ,  immunoassay ,  cortex ,  telencephalon

Author keywords (5)： Ninein ,  Quaking ,  RNA-binding protein ,  HITS-CLIP ,  neural development

JST classification (2)： Gene expression  (EC02040Q) ,  Biological function  (EB03040U)

Reference (38)：

• Boutz, P.L.; Stoilov, P.; Li, Q.; Lin, C.H.; Chawla, G.; Ostrow, K.; Shiue, L.; Ares, M.J.; Black, D.L. A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev. 2007, 21, 1636-1652.
• Darnell, R.B. RNA protein interaction in neurons. Annu. Rev. Neurosci. 2013, 36, 243-270.
• Gerstberger, S.; Hafner, M.; Tuschl, T. A census of human RNA-binding proteins. Nat. Rev. Genet. 2014, 15, 829-845.
• Zhang, C.; Zhang, Z.; Castle, J.; Sun, S.; Johnson, J.; Krainer, A.R.; Zhang, M.Q. Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes Dev. 2008, 22, 2550-2563.
• Raj, B.; Blencowe, B.J. Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles. Neuron 2015, 87, 14-27.

Terms in the title (5)： エキソン ,  RNA ,  神経幹細胞 ,  RNA結合蛋白質 ,  調節