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J-GLOBAL ID：201902215250421268   Reference number：19A0625778

Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing

ゲノム編集により導入された病原性MSH2変異を有するヒト細胞における異なるゲノム不安定化【JST・京大機械翻訳】

Author (11)： Hayashida Genki (Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences, Kyushu University, Japan) ,  Hayashida Genki (Department of Biology, School of Sciences, Kyushu University, Fukuoka, Japan) ,  Shioi Seijiro (Clinical Research Institute, Cancer Genetics Laboratory, National Kyushu Cancer Center, Fukuoka, Japan) ,  Hidaka Kyoko (Centre for Fundamental Education, University of Kitakyushu, Kitakyushu, Japan) ,  Fujikane Ryosuke (Department of Odontology and Fukuoka Dental College, Fukuoka, Japan) ,  Hidaka Masumi (Department of Odontology and Fukuoka Dental College, Fukuoka, Japan) ,  Tsurimoto Toshiki (Department of Biology, School of Sciences, Kyushu University, Fukuoka, Japan) ,  Tsuzuki Teruhisa (Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences, Kyushu University, Japan) ,  Tsuzuki Teruhisa (Advanced Science Research Center, Fukuoka Dental College, Fukuoka, Japan) ,  Oda Shinya (Clinical Research Institute, Cancer Genetics Laboratory, National Kyushu Cancer Center, Fukuoka, Japan) ,  Nakatsu Yoshimichi (Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences, Kyushu University, Japan)
Material： Experimental Cell Research  (Exp Cell Res)
Volume： 377  Issue： 1-2  Page： 24-35  Publication year： 2019 
JST Material Number： B0313A  ISSN： 0014-4827  CODEN： ECREAL  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Repeat destabilisation is vari...

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Thesaurus term： phenotype ,  mutation ,  *human(primates) ,  clone ,  *variation(biology) ,  microsatellite ,  alkylating agent ,  DNA ,  mismatch repair ,  tumor ,  HeLa cell ,  knockout mouse
Semi thesaurus term： Cas9 ,  *不安定化 ,  *MutSホモログ2蛋白質 , 【Automatic Indexing@JST】

Author keywords (5)： CRISPR/Cas9 ,  DNA mismatch repair ,  Lynch syndrome ,  Genomic instability ,  Microsatelites

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Function of cell components  (EF03060C)

Terms in the title (7)： ゲノム編集 ,  病原性 ,  MSH2 ,  変異 ,  ヒト ,  細胞 ,  ゲノム不安定化