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J-GLOBAL ID：201902215704785257   Reference number：19A1861461

Protein Tyrosine Phosphatase Inhibitor, Orthovanadate, Induces Contraction via Rho Kinase Activation in Mouse Thoracic Aortas

蛋白質チロシンホスファターゼ阻害剤オルトバナジン酸はマウス胸部大動脈におけるRhoキナーゼ活性化を介して収縮を誘導する

Author (5)： Terada Yuka (Laboratory of Cardiovascular Pharmacology, Department of Biopharmaceutical Sciences, Kobe Gakuin University) ,  Higashi Naoki (Laboratory of Cardiovascular Pharmacology, Department of Biopharmaceutical Sciences, Kobe Gakuin University) ,  Hidaka Yuki (Laboratory of Cardiovascular Pharmacology, Department of Biopharmaceutical Sciences, Kobe Gakuin University) ,  Isomoto Yasumasa (Laboratory of Cardiovascular Pharmacology, Department of Biopharmaceutical Sciences, Kobe Gakuin University) ,  Yayama Katsutoshi (Laboratory of Cardiovascular Pharmacology, Department of Biopharmaceutical Sciences, Kobe Gakuin University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 6  Page： 877-885(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： Erk1/2 ,...

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Author keywords (8)： myosin light chain phosphatase ,  orthovanadate ,  thoracic aorta ,  mouse ,  myosin light chain phosphatase ,  orthovanadate ,  thoracic aorta ,  mouse

JST classification (2)： Vasculature  (EJ04030O) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Reference (45)：

• 1) Cantley LC Jr, Josephson L, Warner R, Yanagisawa M, Lechene C, Guidotti G. Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. J. Biol. Chem., 252, 7421-7423 (1977).
• 2) Swarup G, Cohen S, Garbers DL. Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate. Biochem. Biophys. Res. Commun., 107, 1104-1109 (1982).
• 3) Chen Y, Chan TM. Orthovanadate and 2,3-dimethoxy-1,4-naphthoquinone augment growth factor-induced cell proliferation and c-fos gene expression in 3T3-L1 cells. Arch. Biochem. Biophys., 305, 9-16 (1993).
• 4) Mehdi MZ, Pandey SK, Theberge JF, Srivastava AK. Insulin signal mimicry as a mechanism for the insulin-like effects of vanadium. Cell Biochem. Biophys., 44, 73-81 (2006).
• 5) Morita A, Yamamoto S, Wang B, Tanaka K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, Hosoi Y, Ikekita M. Sodium orthovanadate inhibits p53-mediated apoptosis. Cancer Res., 70, 257-265 (2010).

Terms in the title (9)： 蛋白質チロシンホスファターゼ ,  阻害剤 ,  オルトバナジン酸 ,  マウス ,  胸部大動脈 ,  Rhoキナーゼ ,  活性化 ,  収縮 ,  誘導