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J-GLOBAL ID：201902215711796302   Reference number：19A1828016

Coixol amplifies glucose-stimulated insulin secretion via cAMP mediated signaling pathway

COIXOLはcAMP仲介シグナル伝達経路を介してグルコース刺激インスリン分泌を増幅する【JST・京大機械翻訳】

Author (14)： Hameed Abdul (Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan) ,  Hameed Abdul (Centre for Advanced Drug Research (CADR), COMSATS University Islamabad (CUI), Abbottabad, 22060, Pakistan) ,  Hafizur Rahman M. (Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan) ,  Khan M. Israr (Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan) ,  Jawed Abira (Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan) ,  Wang Hao (Laboratory of Molecular Endocrinology and Metabolism, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan) ,  Zhao Miaomiao (Laboratory of Molecular Endocrinology and Metabolism, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan) ,  Matsunaga Kohichi (Laboratory of Molecular Endocrinology and Metabolism, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan) ,  Izumi Tetsuro (Laboratory of Molecular Endocrinology and Metabolism, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan) ,  Siddiqui Sonia (Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan) ,  Khan Faisal (Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan) ,  Adhikari Achyut (H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan) ,  Adhikari Achyut (Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal) ,  Sharma Khaga Raj (Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal)
Material： European Journal of Pharmacology  (Eur J Pharmacol)
Volume： 858  Page： Null  Publication year： 2019 
JST Material Number： B0841A  ISSN： 0014-2999  CODEN： EJPHAZ  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Recently, we reported the role...

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Thesaurus term： additive effect ,  sugar tolerance ,  in vitro experiment ,  Diabetes Mellitus ,  Mus musculus ,  electric current ,  *Islets of Langerhans ,  Epac 2 ,  MIN6 cell ,  *insulin secretion ,  Myomorpha ,  hexose ,  aldose ,  adenine nucleotide ,  ribonucleotide ,  cyclic nucleotide
Semi thesaurus term： 阻害剤 ,  アンタゴニスト ,  アゴニスト , 【Automatic Indexing@JST】

Author keywords (6)： Coixol ,  Insulin secretion ,  Mice islets ,  Protein kinase A ,  Epac2 ,  Intracellular cAMP

JST classification (5)： Basic research of drugs acting on carbohydrate metabolism  (GW13020Q) ,  Basic research of drugs acting on lipid metabolism  (GW13040M) ,  Basic research of drugs acting on digestive system  (GW09010Q) ,  Pancreas  (EJ06050Y) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (2)： Glucose ,  cAMP

Terms in the title (7)： cAMP ,  仲介 ,  シグナル伝達経路 ,  グルコース ,  刺激 ,  インスリン分泌 ,  増幅