Art

J-GLOBAL ID：201902215761061207   Reference number：19A0768001

Development of a Ligand Screening Tool Using Full-Length Human Peroxisome Proliferator-Activated Receptor-Expressing Cell Lines to Ameliorate Metabolic Syndrome

メタボリックシンドロームを改善するための完全長ヒトペルオキシソーム増殖因子活性化受容体発現細胞株を用いたリガンドスクリーニングツールの開発

Author (12)： Tachibana Keisuke (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Ishimoto Kenji (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Takahashi Rika (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Kadono Hirokazu (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Awaji Takuya (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Yuzuriha Tomohiro (Faculty of Pharmaceutical Sciences, Setsunan University) ,  Tanaka Toshiya (Laboratory for System Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo) ,  Hamakubo Takao (Department of Protein-Protein Interaction Research, Institute for Advanced Medical Sciences, Nippon Medical School) ,  Sakai Juro (Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo) ,  Kodama Tatsuhiko (Laboratory for System Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo) ,  Aoki Shunji (School of Pharmacy, Hyogo University of Health Sciences) ,  Doi Takefumi (Graduate School of Pharmaceutical Sciences, Osaka University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 67  Issue： 3  Page： 199-202(J-STAGE)  Publication year： 2019 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Rutaceae ,...
Semi thesaurus term： Evodia ,...

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Author keywords (12)： peroxisome proliferator-activated receptor ,  ligand ,  screening system ,  natural resource ,  Tet-off system ,  nuclear receptor ,  peroxisome proliferator-activated receptor ,  ligand ,  screening system ,  natural resource ,  Tet-off system ,  nuclear receptor

JST classification (3)： Basic research of drugs acting on carbohydrate metabolism  (GW13020Q) ,  Alkaloids  (CF10030D) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (1)： Evodiamine

Reference (12)：

• 1) Tachibana K., Kobayashi Y., Tanaka T., Tagami M., Sugiyama A., Katayama T., Ueda C., Yamasaki D., Ishimoto K., Sumitomo M., Uchiyama Y., Kohro T., Sakai J., Hamakubo T., Kodama T., Doi T., Nucl. Recept., 3, 3 (2005).
• 2) Desvergne B., Wahli W., Endocr. Rev., 20, 649-688 (1999).
• 3) Tachibana K., Yamasaki D., Ishimoto K., Doi T., PPAR Res., 2008, 102737 (2008).
• 4) Berbaum J., Harrison R. K., Anal. Biochem., 339, 121-128 (2005).
• 5) Hummasti S., Tontonoz P., Mol. Endocrinol., 20, 1261-1275 (2006).

Terms in the title (6)： メタボリックシンドローム ,  ヒト ,  ペルオキシソーム増殖因子活性化受容体 ,  発現 ,  細胞株 ,  開発