Art

J-GLOBAL ID：201902216492442233   Reference number：19A2639575

Identification of lead-produced lipid hydroperoxides in human HepG2 cells and protection using rosmarinic and ascorbic acids with a reference to their regulatory roles on Nrf2-Keap1 antioxidant pathway

ヒトHepG2細胞における鉛産生脂質ヒドロペルオキシドの同定およびロスマリン酸およびアスコルビン酸を用いた保護作用とNrf2-Keap1抗酸化経路に対するそれらの調節的役割に関する研究【JST・京大機械翻訳】

Author (9)： Li Yonghan (Laboratory of Advanced Lipid Analysis, Faculty of Health Sciences, Hokkaido University, Kita 12, Nishi 5, Sapporo, 060-0812, Japan) ,  Darwish Wageh Sobhy (Laboratory of Advanced Lipid Analysis, Faculty of Health Sciences, Hokkaido University, Kita 12, Nishi 5, Sapporo, 060-0812, Japan) ,  Darwish Wageh Sobhy (Food Control Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt) ,  Chen Zhen (Laboratory of Advanced Lipid Analysis, Faculty of Health Sciences, Hokkaido University, Kita 12, Nishi 5, Sapporo, 060-0812, Japan) ,  Hui Tan (Laboratory of Advanced Lipid Analysis, Faculty of Health Sciences, Hokkaido University, Kita 12, Nishi 5, Sapporo, 060-0812, Japan) ,  Wu Yue (Laboratory of Advanced Lipid Analysis, Faculty of Health Sciences, Hokkaido University, Kita 12, Nishi 5, Sapporo, 060-0812, Japan) ,  Hirotaka Suzuki (Laboratory of Advanced Lipid Analysis, Faculty of Health Sciences, Hokkaido University, Kita 12, Nishi 5, Sapporo, 060-0812, Japan) ,  Chiba Hitoshi (Department of Nutrition, Sapporo University of Health Sciences, Nakanuma Nishi 4-2-1-15, Higashi Ku, Sapporo, 007-0894, Japan) ,  Hui Shu-Ping (Laboratory of Advanced Lipid Analysis, Faculty of Health Sciences, Hokkaido University, Kita 12, Nishi 5, Sapporo, 060-0812, Japan)
Material： Chemico-Biological Interactions  (Chem Biol Interact)
Volume： 314  Page： Null  Publication year： 2019 
JST Material Number： H0058B  ISSN： 0009-2797  CODEN： CBINA  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Lead (Pb) is one of the toxic ...

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Thesaurus term： *antioxidation ,  lipid peroxidation ,  *HepG2 cell ,  *human(primates) ,  quantitative polymerase chain reaction ,  cytotoxicity ,  inflammation ,  *lead ,  oxidative stress ,  LC-MS analysis ,  *protective action ,  lactone ,  water-soluble vitamin ,  secondary alcohol ,  polyol
Semi thesaurus term： 抗酸化酵素 ,  *Keap1蛋白質 ,  *NFE2関連因子2 , 【Automatic Indexing@JST】

Author keywords (6)： Lead ,  HepG2 cells ,  Lipid hydroperoxides ,  Rosmarinic acid ,  Ascorbic acid ,  Nrf2

JST classification (3)： Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q) ,  Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (1)： Ascorbic Acid

Terms in the title (15)： ヒト ,  HepG2細胞 ,  鉛 ,  脂質ヒドロペルオキシド ,  同定 ,  ロスマリン酸 ,  アスコルビン酸 ,  保護作用 ,  NRF2 ,  Keap1 ,  酸化 ,  経路 ,  調節 ,  役割 ,  研究