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J-GLOBAL ID：201902216726580239   Reference number：19A1861309

Inhibitory Effect of Polypodium Leucotomos Extract on Cytochrome P450 3A-mediated Midazolam Metabolism

チトクロームP450 3A媒介ミダゾラム代謝に及ぼすPolypodium leucotomos抽出物の阻害効果

Author (8)： GOMI Yurika (Department of Pharmacology, Showa University School of Medicine) ,  GOMI Yurika (Department of Dermatology, Showa University School of Medicine) ,  NISHIMURA Yuki (Department of Pharmacology, Showa University School of Medicine) ,  KURATA Norimitsu (Faculty of Arts and Sciences at Fujiyoshida) ,  IWASE Mariko (Department of Pharmacology, Showa University School of Medicine) ,  SHINYA Koichiro (Department of Pharmacology, Showa University School of Medicine) ,  SHINYA Koichiro (Department of Dermatology, Showa University School of Medicine) ,  KIUCHI Yuji (Department of Pharmacology, Showa University School of Medicine)
Material： Showa University Journal of Medical Sciences  (Showa Univ J Med Sci)
Volume： 31  Issue： 1  Page： 29-39(J-STAGE)  Publication year： 2019 
JST Material Number： L1154A  ISSN： 0915-6380  CODEN： SUMSEG  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： cytochrome P450 ,...
Semi thesaurus term： *Polypodium leucotomos ,...

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Author keywords (4)： food-drug interaction ,  cytochrome P450 ,  Polypodium leucotomos ,  CYP3A

JST classification (2)： Interactions of drugs  (GV01070X) ,  Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (1)： Midazolam

Reference (28)：

• 1) Kohli I, Shafi R, Isedeh P, et al. The impact of oral Polypodium leucotomos extract on ultraviolet B response: a human clinical study. J Am Acad Dermatol. 2017;77:33-41.
• 2) Choudlhry SZ, Bhatia N, Ceilley R, et al. Role of oral Polypodium leucotomos extract in dermatologic diseases: a review of the literature. J Drugs Dermatol. 2014;13:148-153.
• 3) Middelkamp-Hup MA, Pathak MA, Parrado C, et al. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. J Am Acad Dermatol. 2004;51:910-918.
• 4) Aguilera P, Carrera C, Puig-Butille JA, et al. Benefits of oral Polypodium leucotomos extract in MM high-risk patients. J Eur Acad Dermatol Venereol. 2013;27:1095-1100.
• 5) Caccialanza M, Recalcati S, Piccinno R. Oral Polypodium leucotomos extract photoprotective activity in 57 patients with idiopathic photodermatoses. G Ital Dermatol Venereol. 2011;146:85-87.

Terms in the title (6)： チトクロームP450 ,  ミダゾラム ,  代謝 ,  Polypodium ,  抽出物 ,  阻害効果