Art

J-GLOBAL ID：201902217288124025   Reference number：19A2328225

ECa 233 Suppresses LPS-Induced Proinflammatory Responses in Macrophages via Suppressing ERK1/2, p38 MAPK and Akt Pathways

ECa233はERK1/2,p38MAPKおよびAkt経路を抑制することによりマクロファージにおけるLPS誘発炎症誘発性応答を抑制する

Author (6)： Sukketsiri Wanida (Department of Pharmacology, Faculty of Science, Prince of Songkla University) ,  Tanasawet Supita (Department of Anatomy, Faculty of Science, Prince of Songkla University) ,  Moolsap Furoida (Department of Pharmacology, Faculty of Science, Prince of Songkla University) ,  Tantisira Mayuree H. (Faculty of Pharmaceutical Science, Burapha University, Chon Buri Campus) ,  Hutamekalin Pilaiwanwadee (Department of Physiology, Faculty of Science, Prince of Songkla University) ,  Tipmanee Varomyalin (Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 8  Page： 1358-1365(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Umbelliferae ,...
Semi thesaurus term： Akt ,...

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Author keywords (10)： Centella asiatica ,  cyclooxygenase-2 ,  inducible nitric oxide synthase ,  reactive oxygen species ,  nuclear factor-kappa B ,  Centella asiatica ,  cyclooxygenase-2 ,  inducible nitric oxide synthase ,  reactive oxygen species ,  nuclear factor-kappa B

JST classification (1)： Basic research of anti-inflammatory drugs  (GW15010T)

Reference (34)：

• 1) Sugimoto MA, Sousa LP, Pinho V, Perretti M, Teixeira MM. Resolution of inflammation: what controls its onset? Front. Immunol., 7, 160 (2016).
• 2) Raetz CRH, Whitfield C. Lipopolysaccharide endotoxins. Annu. Rev. Biochem., 71, 635-700 (2002).
• 3) Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell. Signal., 13, 85-94 (2001).
• 4) Laskin DL, Sunil VR, Gardner CR, Laskin JD. Macrophages and tissue injury: agents of defense or destruction? Annu. Rev. Pharmacol. Toxicol., 51, 267-288 (2011).
• 5) McNelis JC, Olefsky JM. Macrophages, immunity, and metabolic disease. Immunity, 41, 36-48 (2014).

Terms in the title (9)： ERK1 ,  p38MAPK ,  Akt ,  経路 ,  マクロファージ ,  LPS ,  誘発 ,  炎症 ,  応答