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J-GLOBAL ID：201902217726089314   Reference number：19A1280480

SPACIA1/SAAL1 Deletion Results in a Moderate Delay in Collagen-Induced Arthritis Activity, along with mRNA Decay of Cyclin-dependent Kinase 6 Gene

SPACIA1/SAAL1欠失はサイクリン依存性キナーゼ6遺伝子のmRNA崩壊に沿ってコラーゲン誘発関節炎活性における中等度遅延をもたらす【JST・京大機械翻訳】

Author (12)： Fujii Ryoji (Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa 216-8512, Japan) ,  Komatsu Rie (Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa 216-8512, Japan) ,  Sato Tomoo (Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa 216-8512, Japan) ,  Seki Iwao (AYUMI Pharmaceutical Corporation, Kyoto 612-8374, Japan) ,  Konomi Koji (Santen Pharmaceutical Co., Ltd., Osaka 533-8651, Japan) ,  Aono Hiroyuki (AYUMI Pharmaceutical Corporation, Kyoto 612-8374, Japan) ,  Niki Hisateru (Department of Orthopedic Surgery, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan) ,  Yudoh Kazuo (Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa 216-8512, Japan) ,  Nishioka Kusuki (Global Health Innovation Policy Program (GHIPP), National Graduate Institute for Policy Studies (GRIPS), Tokyo 106-8677, Japan) ,  Nakajima Toshihiro (Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa 216-8512, Japan) ,  Nakajima Toshihiro (Institute of Medical Science, Tokyo Medical University, Tokyo 160-8402, Japan) ,  Nakajima Toshihiro (Misato Marine Hospital, Kochi 781-0112, Japan)
Material： International Journal of Molecular Sciences (Web)  (Int J Mol Sci (Web))
Volume： 19  Issue： 12  Page： 3828  Publication year： 2018 
JST Material Number： U7038A  ISSN： 1422-0067  CODEN： IJMCFK  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： This study was performed to el...

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Thesaurus term： *cyclin-dependent kinase ,  serum amyloid A ,  *gene ,  rheumatoid arthritis ,  gene expression ,  Cell Cycle ,  human ,  siRNA ,  Up-Regulation ,  wild-type mouse ,  mouse model ,  Synoviocytes ,  Models, Animal ,  *mRNA decay ,  *serine-threonine kinase ,  glycoprotein ,  molecular genetic phenomenon
Semi thesaurus term： *コラーゲン誘発関節炎 , 【Automatic Indexing@JST】

Author keywords (6)： cell cycle ,  collagen-induced arthritis ,  cyclin-dependent kinase ,  proliferation ,  rheumatoid arthritis ,  synovitis

JST classification (2)： Cell physiology in general  (EF02010S) ,  Basic medicine on musculoskeletal system  (GG01020B)

Reference (11)：

• Harris, E.D. Jr. Rheumatoid arthritis. Pathophysiology and implications for therapy. N. Engl. J. Med. 1990, 322, 1277-1289.
• Tanaka, Y.; Yamaoka, K. JAK inhibitor tofacitinib for treating rheumatoid arthritis: From basic to clinical. Mod. Rheumatol. 2013, 23, 415-424.
• Ruderman, E.M. The role of concomitant methotrexate in biologic therapy for rheumatoid arthritis. Bull. Hosp. Jt. Dis. 2013, 71, S29-S32.
• Chan, E.S.; Cronstein, B.N. Methotrexate--how does it really work? Nat. Rev. Rheumatol. 2010, 6, 175-178.
• Sekine, C.; Sugihara, T.; Miyake, S.; Hirai, H.; Yoshida, M.; Miyasaka, N.; Kohsaka, H. Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors. J. Immunol. 2008, 180, 1954-1961.

Terms in the title (7)： 欠失 ,  サイクリン依存性キナーゼ6 ,  遺伝子 ,  mRNA崩壊 ,  コラーゲン誘発関節炎 ,  活性 ,  遅延