Art

J-GLOBAL ID：201902217988602166   Reference number：19A1711503

Bouchardatine analogue alleviates non-alcoholic hepatic fatty liver disease/non-alcoholic steatohepatitis in high-fat fed mice by inhibiting ATP synthase activity

bouカルダチン類似体はATPシンターゼ活性阻害により高脂肪食マウスにおける非アルコール性肝脂肪肝疾患/非アルコール性脂肪肝炎を軽減する【JST・京大機械翻訳】

Author (12)： Rao Yong (Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China) ,  Lu Yu-Ting (Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China) ,  Li Chan (Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China) ,  Song Qin-Qin (Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China) ,  Xu Yao-Hao (Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China) ,  Xu Zhao (Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China) ,  Hu Yu-Tao (Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China) ,  Yu Hong (Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China) ,  Gao Lin (Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China) ,  Gu Lian-Quan (Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China) ,  Ye Ji-Ming (Lipid Biology and Metabolic Disease Laboratory, School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia) ,  Huang Zhi-Shu (Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China)
Material： British Journal of Pharmacology  (Br J Pharmacol)
Volume： 176  Issue： 16  Page： 2877-2893  Publication year： 2019 
JST Material Number： B0334A  ISSN： 0007-1188  CODEN： BJPCB  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： BACKGROUND AND PURPOSE: Non-al...

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Thesaurus term： *Mus musculus ,  Inflammation ,  oxidative stress ,  Collagen ,  deposition ,  siRNA ,  triglyceride ,  Apoptosis ,  alanine aminotransferase ,  metabolic syndrome ,  macrophage ,  Western blotting ,  *Fatty Liver ,  kinase ,  STK11 protein ,  *Myomorpha ,  Scleroproteins ,  animal protein ,  bioassay
Semi thesaurus term： LKB1 , 【Automatic Indexing@JST】

JST classification (5)： Transport of cell membrane  (EF04020R) ,  Basic research of drugs acting on lipid metabolism  (GW13040M) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q) ,  Basic medicine on digestive system  (GH01020E)

Terms in the title (9)： 類似体 ,  ATPシンターゼ ,  活性 ,  阻害 ,  高脂肪食 ,  マウス ,  アルコール ,  脂肪肝疾患 ,  非アルコール性脂肪肝炎