Art

J-GLOBAL ID：201902218164604221   Reference number：19A1287255

Inhibitory Effects of Sodium Alginate on Hepatic Steatosis in Mice Induced by a Methionine- and Choline-Deficient Diet

メチオニンおよびコリン欠乏食により誘導されたマウスにおける肝脂肪症に対するアルギン酸ナトリウムの阻害効果【JST・京大機械翻訳】

Author (9)： Kawauchi Shoji (Education and Research Center for Clinical Pharmacy, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Japan) ,  Horibe Sayo (Laboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Japan) ,  Sasaki Naoto (Laboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Japan) ,  Tanahashi Toshihito (Laboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Japan) ,  Tanahashi Toshihito (Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Mizuno Shigeto (Laboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Japan) ,  Mizuno Shigeto (Endoscopy Department, Kindai University Nara Hospital, 1248-1 Otoda-cho, Ikoma 630-0293, Japan) ,  Hamaguchi Tsuneo (Education and Research Center for Clinical Pharmacy, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Japan) ,  Rikitake Yoshiyuki (Laboratory of Medical Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Japan)
Material： Marine Drugs (Web)
Volume： 17  Issue： 2  Page： 104  Publication year： 2019 
JST Material Number： U7236A  ISSN： 1660-3397  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Nonalcoholic steatohepatitis (...

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Thesaurus term： Collagen ,  Mucus ,  human ,  *Fatty Liver ,  Inflammation ,  small intestine ,  villus ,  Hepatitis ,  therapy ,  pathogenesis ,  mRNA expression ,  invasion ,  *alginate sodium ,  Phaeophyceae ,  Scleroproteins ,  animal protein ,  algae ,  Cryptogamae ,  aliphatic amine ,  sulfide (organic) ,  aliphatic carboxylic acid ,  sulfur containing amino acid ,  primary amine
Semi thesaurus term： Phaeophyceae ,  非アルコール性脂肪性肝炎 , 【Automatic Indexing@JST】

Author keywords (4)： nonalcoholic steatohepatitis ,  sodium alginate ,  methionine and choline deficient ,  intestinal barrier function

JST classification (4)： Basic medicine on digestive system  (GH01020E) ,  Protein  (FJ09020N) ,  Basic research of pharmacology of crude drugs  (GX06020J) ,  Food chemistry,nutritional value  (FJ01020J)

Substance index (1)： Methionine

Reference (28)：

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• Neuschwander-Tetri, B.A.; Loomba, R.; Sanyal, A.J.; Lavine, J.E.; Van Natta, M.L.; Abdelmalek, M.F.; Chalasani, N.; Dasarathy, S.; Diehl, A.M.; Hameed, B.; et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial. Lancet 2015, 385, 956-965.

Terms in the title (7)： メチオニン ,  コリン欠乏 ,  誘導 ,  マウス ,  肝脂肪症 ,  アルギン酸ナトリウム ,  阻害効果