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J-GLOBAL ID：201902218181032263   Reference number：19A1782686

Fluorine-18 (¹⁸F)-labeled retinoid x receptor (RXR) partial agonist whose tissue transferability is affected by other RXR ligands

組織移行性が他のRXRリガンドにより影響されるフッ素-18(18F)標識レチノイドX受容体(RXR)部分アゴニスト【JST・京大機械翻訳】

Author (10)： Takamura Yuta (Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Kita-Ku, Okayama 700-8530, Japan) ,  Shibahara Osamu (Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Kita-Ku, Okayama 700-8530, Japan) ,  Watanabe Masaki (Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Kita-Ku, Okayama 700-8530, Japan) ,  Fujihara Michiko (Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Kita-Ku, Okayama 700-8530, Japan) ,  Fujihara Michiko (AIBIOS Co. Ltd. Tri-Seven Roppongi, 8F 7-7-7 Roppongi, Minato-ku, Tokyo 106-0032 Japan) ,  Yamada Shoya (Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Kita-Ku, Okayama 700-8530, Japan) ,  Akehi Masaru (Collaborative Research Center for OMIC, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama 700-8558, Japan) ,  Sasaki Takanori (Collaborative Research Center for OMIC, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama 700-8558, Japan) ,  Hirano Hiroyuki (SHI Accelerator Service Ltd., 1-17-6 Osaki Shinagawa-Ku, Tokyo 141-0032, Japan) ,  Kakuta Hiroki (Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Kita-Ku, Okayama 700-8530, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 27  Issue： 14  Page： 3128-3134  Publication year： 2019 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Bexarotene (1), a retinoid X r...

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Thesaurus term： *fluorine ,  *tissue concentration ,  *retinoid X receptor ,  pharmacokinetics ,  blood concentration ,  visualization ,  administration (biology) ,  PET (tomography) ,  *Retinoids ,  coadministration ,  non-specific binding ,  fat-soluble
Semi thesaurus term： *アゴニスト ,  皮膚T細胞リンパ腫 ,  *部分作動薬 , 【Automatic Indexing@JST】

Author keywords (6)： ¹⁸F ,  Nuclear receptors ,  PET imaging ,  Pharmacokinetics ,  Retinoids ,  RXR

JST classification (4)： Labeled compounds  (CB10050N) ,  Receptors on cell membrane  (EF04030C) ,  Basic research of diagnostic drugs  (GW20010P) ,  Basic research of radiopharmaceuticals  (GW18010O)

Terms in the title (7)： 組織移行性 ,  RXR ,  リガンド ,  フッ素 ,  標識 ,  レチノイドX受容体 ,  部分アゴニスト