Art

J-GLOBAL ID：201902218986650303   Reference number：19A0393666

A designed cell-penetrating human SOCS2 protein suppresses GH-dependent cancer cell proliferation

設計された細胞透過性ヒトSOCS2蛋白質はGH依存性癌細胞増殖を抑制する

Author (5)： MIYAMOTO Azusa (Nihon Univ., Kanagawa, JPN) ,  MASUHIRO Yoshikazu (Nihon Univ., Kanagawa, JPN) ,  SEKI Taiichiro (Nihon Univ., Kanagawa, JPN) ,  HANAZAWA Shigemasa (Nihon Univ., Kanagawa, JPN) ,  SHIBA Hajime (Nihon Univ., Kanagawa, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 83  Issue： 2  Page： 300-308  Publication year： Feb. 2019 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： antitumor action ,...
Semi thesaurus term： *Suppressor of Cytokine Signaling Proteins ,...

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JST classification (2)： Biological function  (EB03040U) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (23)：

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• Boguszewski CL, Boguszewski MC, Kopchick JJ. Growth hormone, insulin-like growth factor system and carcinogenesis. Endokrynol Pol. 2016;67:414-426.
• Chanson P, Salenava S, Kamenicky P. Acromegaly. Handb Clin Neurol. 2014;124:197-219.
• Ahmed SF, Farquharson C. The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins. J Endocrinol. 2010;206:249-259.
• Greenhalgh CJ, Bartolino P, Asa SL, et al. Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol Endocrinol. 2002;16:1394-1406.

Terms in the title (9)： 設計 ,  細胞 ,  透過性 ,  ヒト ,  蛋白質 ,  GH ,  依存性 ,  癌細胞 ,  増殖