Art
J-GLOBAL ID：201902219692349525   Reference number：19A2643085

Development of an in vitro cholestatic drug-induced liver injury evaluation system using HepG2-hNTCP-C4 cells in sandwich configuration

サンドイッチ構造におけるHepG2-HNTCP-C4細胞を用いたin vitro胆汁うっ滞薬誘発肝損傷評価システムの開発【JST・京大機械翻訳】
Author (6)：
Sakai Yoko

About Sakai Yoko

(Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan)

About Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan

, 
Okumura Hiroki

About Okumura Hiroki

(Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan)

About Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan

, 
Iwao Takahiro

About Iwao Takahiro

(Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan)

About Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan

, 
Watashi Koichi

About Watashi Koichi

(Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan)

About Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

, 
Ito Kousei

About Ito Kousei

(Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan)

About Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan

, 
Matsunaga Tamihide

About Matsunaga Tamihide

(Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan)

About Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan


Material：
Toxicology in Vitro  (Toxicol Vitr)

About Toxicology in Vitro


Volume： 61  Page： Null  Publication year： 2019 
JST Material Number： T0472A  ISSN： 0887-2333  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
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Toxicological approaches in sc...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
cytotoxicity

About cytotoxicity

, 
*bile

About bile

, 
*HepG2 cell

About HepG2 cell

, 
bile acid

About bile acid

, 
human(primates)

About human(primates)

, 
hepatocyte

About hepatocyte

, 
toxin

About toxin

, 
substrate(biochemistry)

About substrate(biochemistry)

, 
clinical trial

About clinical trial

, 
*in vitro experiment

About in vitro experiment

, 
*cholestasis

About cholestasis

, 
characterization

About characterization

, 
screening(inspection)

About screening(inspection)

, 
culture(biology)

About culture(biology)


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*ナトリウムタウロコール酸共輸送ポリペプチド

About ナトリウムタウロコール酸共輸送ポリペプチド

, 【Automatic Indexing@JST】
Author keywords (5)：
Bile acids

About Bile acids

, 
Sandwich culture

About Sandwich culture

, 
HepG2-hNTCP-C4 cells

About HepG2-hNTCP-C4 cells

, 
Drug-induced liver injury

About Drug-induced liver injury

, 
Na+-taurocholate cotransporting polypeptide

About Na+-taurocholate cotransporting polypeptide

JST classification (2)：
JST classification
Category name(code) classified by JST.
Toxicity of organic compounds 
(GZ02030Y)

About Toxicity of organic compounds

,  Toxicology in general 
(GZ01000K)

About Toxicology in general

Terms in the title (9)：
Terms in the title
Keywords automatically extracted from the title.
サンドイッチ構造

About サンドイッチ構造

, 
HepG2

About HepG2

, 
C4

About C4

, 
細胞

About 細胞

, 
胆汁うっ滞

About 胆汁うっ滞

, 
誘発

About 誘発

, 
肝損傷

About 肝損傷

, 
評価システム

About 評価システム

, 
開発

About 開発


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