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J-GLOBAL ID：201902220091935982   Reference number：19A0980873

Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity

C型肝炎ウイルス感染時のセレン蛋白質P mRNAの誘導はRIG-I媒介抗ウイルス免疫を阻害する【JST・京大機械翻訳】

Author (17)： Murai Kazuhisa (Department of Laboratory Medicine, Kanazawa University Graduate School of Health Medicine, Kanazawa, Japan) ,  Honda Masao (Department of Laboratory Medicine, Kanazawa University Graduate School of Health Medicine, Kanazawa, Japan) ,  Honda Masao (Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan) ,  Shirasaki Takayoshi (Department of Laboratory Medicine, Kanazawa University Graduate School of Health Medicine, Kanazawa, Japan) ,  Shimakami Tetsuro (Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan) ,  Omura Hitoshi (Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan) ,  Misu Hirofumi (Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medicine, Kanazawa, Japan) ,  Kita Yuki (Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medicine, Kanazawa, Japan) ,  Takeshita Yumie (Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medicine, Kanazawa, Japan) ,  Ishii Kiyo-aki (Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medicine, Kanazawa, Japan) ,  Takamura Toshinari (Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medicine, Kanazawa, Japan) ,  Urabe Takeshi (Public Central Hospital of Matto Ishikawa, Hakusan, Ishikawa, Japan) ,  Shimizu Ryogo (Department of Laboratory Medicine, Kanazawa University Graduate School of Health Medicine, Kanazawa, Japan) ,  Okada Hikari (Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan) ,  Yamashita Taro (Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan) ,  Sakai Yoshio (Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan) ,  Kaneko Shuichi (Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan)
Material： Cell Host & Microbe
Volume： 25  Issue： 4  Page： 588-601.e7  Publication year： 2019 
JST Material Number： W2784A  ISSN： 1931-3128  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Patients infected with hepatit...

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Thesaurus term： immunological tolerance ,  natural immunity ,  gene ,  hepatocyte ,  human(primates) ,  serum ,  *mRNA ,  interferon ,  up-regulation ,  *hepatitis C virus ,  serum concentration ,  sensor ,  antiviral drug ,  insulin resistance
Semi thesaurus term： ウイルスRNA ,  *RIG-I , 【Automatic Indexing@JST】

Author keywords (9)： hepatokine ,  selenoprotein P ,  hepatitis C virus ,  retinoic-acid-inducible gene I ,  interferon ,  innate immunity ,  chronic hepatitis C ,  type 2 diabetes ,  direct-acting antiviral drugs

JST classification (2)： Physiology and pathogenicity of virus infection  (EG04042Y) ,  Infectious immunity  (ED03030P)

Terms in the title (7)： C型肝炎ウイルス感染 ,  セレン蛋白質P ,  mRNA ,  誘導 ,  RIG-I ,  ウイルス免疫 ,  阻害