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J-GLOBAL ID：201902220703833173   Reference number：19A1474869

A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection

ホスホイノシチド3-キナーゼ由来ペプチドはエンドサイトーシスとインフルエンザウイルス感染を阻害する

Author (14)： Fujioka Yoichiro (Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University) ,  Satoh Aya O. (Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University) ,  Horiuchi Kosui (Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University) ,  Fujioka Mari (Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University) ,  Tsutsumi Kaori (Department of Biological Sciences and Engineering, Faculty of Health Sciences, Hokkaido University) ,  Sasaki Junko (Department of Biochemical Pathophysiology, Medical Research Institute, Tokyo Medical and Dental University) ,  Nepal Prabha (Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University) ,  Kashiwagi Sayaka (Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University) ,  Paudel Sarad (Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University) ,  Nishide Shinya (Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University) ,  Nanbo Asuka (Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University) ,  Sasaki Takehiko (Department of Biochemical Pathophysiology, Medical Research Institute, Tokyo Medical and Dental University) ,  Ohba Yusuke (Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University) ,  Ohba Yusuke (Whitman Center, Marine Biological Laboratory)
Material： Cell Structure and Function (Web)  (Cell Struct Funct (Web))
Volume： 44  Issue： 1  Page： 61-74(J-STAGE)  Publication year： 2019 
JST Material Number： U0126A  ISSN： 1347-3700  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Phosphatidylinositol 3-Kinase ,...
Semi thesaurus term： cellular signal transduction ,...

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Author keywords (5)： signal transduction ,  endocytosis ,  endosome ,  imaging ,  influenza virus

JST classification (3)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S) ,  Infectious diseases,parasitics diseases in general.  (GD01010H)

Reference (29)：

• Domchek, S.M., Auger, K.R., Chatterjee, S., Burke, T.R., and Shoelson, S.E. 1992. Inhibition of SH2 domain/phosphoprotein association by a nonhydrolyzable phosphonopeptide. Biochemistry, 31: 9865-9870.
• Fujioka, Y., Tsuda, M., Hattori, T., Sasaki, J., Sasaki, T., Miyazaki, T., and Ohba, Y. 2011. The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses. PLoS ONE, 6: e16324.
• Fujioka, Y., Tsuda, M., Nanbo, A., Hattori, T., Sasaki, J., Sasaki, T., Miyazaki, T., and Ohba, Y. 2013. A Ca²⁺-dependent signalling circuit regulates influenza A virus internalization and infection. Nat. Commun., 4: 2763.
• Fujioka, Y., Nishide, S., Ose, T., Suzuki, T., Kato, I., Fukuhara, H., Fujioka, M., Horiuchi, K., Satoh, A.O., Nepal, P., et al. 2018. A Sialylated Voltage-Dependent Ca²⁺ Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells. Cell Host Microbe, 23: 809-818.
• Godlee, C. and Kaksonen, M. 2013. Review series: From uncertain beginnings: initiation mechanisms of clathrin-mediated endocytosis. J. Cell Biol., 203: 717-725.

Terms in the title (6)： ホスホイノシチド3-キナーゼ ,  ペプチド ,  エンドサイトーシス ,  インフルエンザ ,  ウイルス感染 ,  阻害