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J-GLOBAL ID：201902220941236289   Reference number：19A1899143

Sex-Specific Effects of Nanoparticle-Encapsulated MitoQ (nMitoQ) Delivery to the Placenta in a Rat Model of Fetal Hypoxia

胎児低酸素症のラットモデルにおける胎盤へのナノ粒子カプセル化MitoQ(NmitoQ)デリバリーの性特異的効果【JST・京大機械翻訳】

Author (19)： Ganguly Esha (1Department of Physiology, University of Alberta, Edmonton, AB, Canada) ,  Ganguly Esha (2Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, AB, Canada) ,  Ganguly Esha (3Women and Children’s Health Research Institute, University of Alberta, Edmonton, AB, Canada) ,  Aljunaidy Mais M. (1Department of Physiology, University of Alberta, Edmonton, AB, Canada) ,  Aljunaidy Mais M. (2Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, AB, Canada) ,  Aljunaidy Mais M. (3Women and Children’s Health Research Institute, University of Alberta, Edmonton, AB, Canada) ,  Kirschenman Raven (2Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, AB, Canada) ,  Kirschenman Raven (3Women and Children’s Health Research Institute, University of Alberta, Edmonton, AB, Canada) ,  Spaans Floor (2Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, AB, Canada) ,  Spaans Floor (3Women and Children’s Health Research Institute, University of Alberta, Edmonton, AB, Canada) ,  Morton Jude S. (2Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, AB, Canada) ,  Morton Jude S. (3Women and Children’s Health Research Institute, University of Alberta, Edmonton, AB, Canada) ,  Phillips Thomas E. J. (4Dementia Research Institute, Cardiff University, Cardiff, United Kingdom) ,  Case C. Patrick (5Musculoskeletal Research Unit, University of Bristol, Bristol, United Kingdom) ,  Cooke Christy-Lynn M. (2Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, AB, Canada) ,  Cooke Christy-Lynn M. (3Women and Children’s Health Research Institute, University of Alberta, Edmonton, AB, Canada) ,  Davidge Sandra T. (1Department of Physiology, University of Alberta, Edmonton, AB, Canada) ,  Davidge Sandra T. (2Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, AB, Canada) ,  Davidge Sandra T. (3Women and Children’s Health Research Institute, University of Alberta, Edmonton, AB, Canada)
Material： Frontiers in Physiology (Web)
Volume： 10  Page： 562  Publication year： 2019 
JST Material Number： U7093A  ISSN： 1664-042X  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Pregnancy complications associ...

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Thesaurus term： *placenta ,  pregnancy ,  *anoxia ,  *rat ,  mRNA ,  *oxygen deficiency ,  superoxide ,  oxidative stress ,  sexual specificity ,  antioxidation ,  prevention ,  adult(person) ,  *fetus ,  human(primates) ,  woman
Semi thesaurus term： 出生 , 【Automatic Indexing@JST】

Author keywords (5)： placenta ,  hypoxia ,  MitoQ ,  nanoparticles ,  sex difference

JST classification (5)： Influence on animals  (EE05040R) ,  Basic gynecology and obstetrics  (GS01020L) ,  Influence on animals  (EE04040K) ,  Clinical medicine on cardiovascular system in general  (GJ01030V) ,  Autecology  (EE03020H)

Reference (67)：

• Aban C. E., Accialini P. L., Etcheverry T., Leguizamon G. F., Martinez N. A., Farina M. G. (2018). Crosstalk between nitric oxide and endocannabinoid signaling pathways in normal and pathological placentation. Front. Physiol. 9:1699. doi: , PMID: doi: 10.3389/fphys.2018.01699
• Abe H., Ishikawa W., Kushima T., Nishimura T., Mori C., Onuki A., et al. (2013). Nitric oxide induces vascular endothelial growth factor expression in the rat placenta in vivo and in vitro. Biosci. Biotechnol. Biochem. 77, 971-976. doi: doi: 10.1271/bbb.120923
• Al-Gubory K. H., Fowler P. A., Garrel C. (2010). The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int. J. Biochem. Cell Biol. 42, 1634-1650. doi: , PMID: doi: 10.1016/j.biocel.2010.06.001
• Aljunaidy M. M., Morton J. S., Cooke C. M., Davidge S. T. (2017). Prenatal hypoxia and placental oxidative stress: linkages to developmental origins of cardiovascular disease. Am. J. Physiol. Regul. Integr. Comp. Physiol. 313, R395-R399. doi: , PMID: doi: 10.1152/ajpregu.00245.2017
• Aljunaidy M. M., Morton J. S., Kirschenman R., Phillips T., Case C. P., Cooke C. M., et al. (2018). Maternal treatment with a placental-targeted antioxidant (MitoQ) impacts offspring cardiovascular function in a rat model of prenatal hypoxia. Pharmacol. Res. 134, 332-342. doi: , PMID: doi: 10.1016/j.phrs.2018.05.006

Terms in the title (8)： 胎児低酸素症 ,  ラット ,  モデル ,  胎盤 ,  ナノ粒子 ,  カプセル化 ,  デリバリー ,  性