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J-GLOBAL ID：201902221512821626   Reference number：19A1529984

Nuclear Progestin Receptor Phosphorylation by Cdk9 Is Required for the Expression of Mmp15, a Protease Indispensable for Ovulation in Medaka

Cdk9による核プロゲスチン受容体リン酸化はメダカにおける排卵に不可欠なプロテアーゼであるMMP15の発現に必要である【JST・京大機械翻訳】

Author (2)： Ogiwara Katsueki ,  Takahashi Takayuki
Material： Cells (Web)
Volume： 8  Issue： 3  Page： 215  Publication year： 2019 
JST Material Number： U7155A  ISSN： 2073-4409  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Ovulation denotes the discharg...

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Thesaurus term： *phosphorylation ,  Cyclins ,  fertilization (reproduction) ,  ovarian follicle ,  *receptor ,  *Ovulation ,  protein kinase ,  promoter (genetics) ,  Oocytes ,  *peptide bond hydrolase ,  *Oryzias latipes ,  *gestagen ,  *Cyclin-Dependent Kinase 9 ,  Proteins ,  *Cyprinodontiformes ,  enzyme inhibitor
Semi thesaurus term： 阻害剤 , 【Automatic Indexing@JST】

Author keywords (7)： medaka ,  ovulation ,  extracellular matrix degradation ,  cyclin-dependent kinase 9 ,  Ccni ,  matrix metalloproteinase 15 expression ,  nuclear progestin receptor phosphorylation

JST classification (3)： Congenital diseases,deformities in general.  (GD03010V) ,  Gene expression  (EC02040Q) ,  Biological function  (EB03040U)

Substance index (1)： Roscovitine

Reference (26)：

• Espey, L.L.; Richards, J.S. Knobil and Neill’s Physiology of Reproduction, 3rd ed.; Neill, J.D., Ed.; Academic Press: Amsterdam, The Netherlands, 2006; Volume 1, pp. 425-474. ISBN 0-12-515401-1.
• Lubzens, E.; Young, G.; Bobe, J.; Cerdà, J. Oogenesis in teleosts: How fish eggs are formed. Gen. Comp. Endocrinol. 2010, 165, 367-389.
• Zhang, Z.; Zhu, B.; Ge, W. Genetic analysis of zebrafish gonadotropin (FSH and LH) functions by TALEN-mediated gene disruption. Mol. Endocrinol. 2015, 29, 76-98.
• Takahashi, A.; Kanda, S.; Abe, T.; Oka, Y. Evolution of the hypothalamic-pituitary-gonadal axis regulation in vertebrates revealed by knockout medaka. Endocrinology 2016, 157, 3994-4002.
• Takahashi, T.; Fujimori, C.; Hagiwara, A.; Ogiwara, K. Recent advances in the understanding of teleost medaka ovulation: The role of proteases and prostaglandins. Zool. Sci. 2013, 30, 239-247.

Terms in the title (9)： Cdk9 ,  核 ,  プロゲスチン ,  受容体 ,  リン酸化 ,  メダカ ,  排卵 ,  プロテアーゼ ,  発現