Art

J-GLOBAL ID：201902221572607488   Reference number：19A1492918

Basophils trigger emphysema development in a murine model of COPD through IL-4-mediated generation of MMP-12-producing macrophages

好塩基球はMMP-12産生マクロファージのIL-4仲介生成を介してCOPDのマウスモデルにおける気腫発生を誘発する【JST・京大機械翻訳】

Author (9)： Shibata Sho (Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan) ,  Shibata Sho (Department of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan) ,  Miyake Kensuke (Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan) ,  Tateishi Tomoya (Department of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan) ,  Yoshikawa Soichiro (Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan) ,  Yamanishi Yoshinori (Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan) ,  Miyazaki Yasunari (Department of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan) ,  Inase Naohiko (Department of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan) ,  Karasuyama Hajime (Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 115  Issue： 51  Page： 13057-13062  Publication year： 2018 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Chronic obstructive pulmonary ...

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Thesaurus term： matrix metalloproteinase ,  alveolar macrophage ,  elastase ,  *chronic obstructive pulmonary disease ,  asthma ,  inflammation ,  *basophils ,  pulmonary alveolus ,  *interleukin 4 ,  monocyte ,  *mouse(animal) ,  Th2 cell ,  *emphysema
Semi thesaurus term： *マウスモデル ,  *マトリックスメタロプロテイナーゼ12 , 【Automatic Indexing@JST】

Author keywords (5)： COPD ,  emphysema ,  basophil ,  IL-4 ,  interstitial macrophage

JST classification (2)： Basic medicine on respiratory system  (GI01020H) ,  Immunological reaction in general  (ED03010T)

Terms in the title (9)： 好塩基球 ,  MMP-12 ,  マクロファージ ,  IL-4 ,  仲介 ,  COPD ,  マウスモデル ,  気腫 ,  誘発