Art

J-GLOBAL ID：201902221978768297   Reference number：19A0791220

Molecular and biochemical characterization of key enzymes in the cysteine and serine metabolic pathways of Acanthamoeba castellanii

Acanthamoeba castellaniiのシステイン及びセリン代謝経路における鍵酵素の分子的及び生化学的特性化【JST・京大機械翻訳】

Author (6)： Wu Duo (Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China) ,  Feng Meng (Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China) ,  Wang Zhi-xin (Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China) ,  Qiao Ke (Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China) ,  Tachibana Hiroshi (Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Japan) ,  Cheng Xun-jia (Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China)
Material： Parasites & Vectors (Web)
Volume： 11  Issue： 1  Page： 604  Publication year： 2018 
JST Material Number： U7341A  ISSN： 1756-3305  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Acanthamoeba spp. can cause se...

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Thesaurus term： forecast ,  Escherichia coli ,  human ,  substrate (biochemistry) ,  enzyme activity ,  recombinant protein ,  Molecular Weight ,  phosphorylation ,  *enzyme ,  gene expression ,  gene ,  biosynthesis ,  *Acanthamoeba ,  *microorganism ,  molecular genetic phenomenon ,  *protozoa ,  *Amoeba ,  *Sarcodina ,  *Rhizopoda ,  amino acid ,  aliphatic amine ,  aliphatic alcohol ,  aliphatic carboxylic acid ,  aminoalcohol ,  hydroxy acid ,  thiol ,  sulfur containing amino acid ,  primary amine
Semi thesaurus term： *Acanthamoeba , 【Automatic Indexing@JST】

Author keywords (5)： Cysteine synthase ,  Cysteine biosynthesis ,  Glycerate dehydrogenase ,  Glycolysis pathway ,  Drug target

JST classification (2)： Infectious diseases,parasitics diseases in general.  (GD01010H) ,  Enzyme in general  (EB09010D)

Substance index (2)： Serine ,  Cysteine

Reference (45)：

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• Parasite; An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment; J Lorenzo-Morales, NA Khan, J Walochnik; 22; 2015; 10; 10.1051/parasite/2015010; citation_id=CR2
• Clin Microbiol Rev; Acanthamoeba spp. as agents of disease in humans; F Marciano-Cabral, G Cabral; 16; 2003; 273-307; 10.1128/CMR.16.2.273-307.2003; citation_id=CR3
• Antimicrob Agents Chemother; Artemether exhibits amoebicidal activity against Acanthamoeba castellanii through inhibition of the serine biosynthesis pathway; Y Deng, W Ran, S Man, X Li, H Gao, W Tang; 59; 2015; 4680-4688; 10.1128/AAC.04758-14; citation_id=CR4
• The Journal of Nutrition; Mammalian Cysteine Metabolism: New Insights into Regulation of Cysteine Metabolism; Martha H. Stipanuk, John E. Dominy, Jeong-In Lee, Relicardo M. Coloso; 136; 6; 2006; 1652S-1659S; 10.1093/jn/136.6.1652S; citation_id=CR5

Terms in the title (6)： Acanthamoeba ,  システイン ,  セリン ,  代謝経路 ,  分子 ,  生化学的特性