Art

J-GLOBAL ID：201902222230130049   Reference number：19A2514939

The Proton Pump Inhibitor Lansoprazole Has Hepatoprotective Effects in In Vitro and In Vivo Rat Models of Acute Liver Injury

プロトンポンプ阻害剤ランソプラゾールは急性肝損傷のin vitroおよびin vivoラットモデルにおいて肝保護効果を有する【JST・京大機械翻訳】

Author (10)： Nakatake Richi (Department of Surgery, Kansai Medical University, Hirakata, Osaka, Japan) ,  Hishikawa Hidehiko (Department of Surgery, Kansai Medical University, Hirakata, Osaka, Japan) ,  Kotsuka Masaya (Department of Surgery, Kansai Medical University, Hirakata, Osaka, Japan) ,  Ishizaki Morihiko (Department of Surgery, Kansai Medical University, Hirakata, Osaka, Japan) ,  Matsui Kosuke (Department of Surgery, Kansai Medical University, Hirakata, Osaka, Japan) ,  Nishizawa Mikio (Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan) ,  Yoshizawa Katsuhiko (Laboratory of Environmental Sciences, Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan) ,  Kaibori Masaki (Department of Surgery, Kansai Medical University, Hirakata, Osaka, Japan) ,  Okumura Tadayoshi (Department of Surgery, Kansai Medical University, Hirakata, Osaka, Japan) ,  Okumura Tadayoshi (Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga, Japan)
Material： Digestive Diseases and Sciences
Volume： 64  Issue： 10  Page： 2854-2866  Publication year： 2019 
JST Material Number： A0919B  ISSN： 0163-2116  CODEN： DDSCD  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： The proton pump inhibitor lans...

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Thesaurus term： hepatocyte ,  *Rattus ,  nitrogen monoxide ,  Neutrophils ,  primary culture ,  human ,  *in vitro experiment ,  lipopolysaccharide ,  Inflammation ,  chemokine ,  NF-kappaB ,  interleukin 1 ,  hepatic dysfunction ,  Nitric Oxide Synthase Type II ,  *hepatoprotective effect ,  *Myomorpha ,  ether ,  sulfoxide ,  nitrogen heterocyclic compound ,  organofluorine compound ,  polynuclear aromatic compound

Author keywords (6)： Primary cultured hepatocytes ,  Acute liver injury ,  Lansoprazole ,  d-galactosamine with lipopolysaccharide ,  Inducible nitric oxide synthase ,  Nuclear factor-kappa B

JST classification (2)： Basic medicine on digestive system  (GH01020E) ,  Basic research of drugs acting on digestive system  (GW09010Q)

Substance index (1)： Lansoprazole

Terms in the title (6)： プロトンポンプ阻害剤 ,  ランソプラゾール ,  肝損傷 ,  ラット ,  モデル ,  肝保護効果