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J-GLOBAL ID：201902222523457866   Reference number：19A0963355

Microtubule Hyperacetylation Enhances KL1-Dependent Micronucleation under a Tau Deficiency in Mammary Epithelial Cells

微小管過アセチル化は乳房上皮細胞におけるタウ欠損下のKL1依存性微小核形成を増強する【JST・京大機械翻訳】

Author (3)： Sudo Haruka (Faculty of Health Science, Tokoha University, 1-30, Mizuochi-cho, Aoi-ku, Shizuoka-shi, Shizuoka 420-0831, Japan) ,  Sudo Haruka (Department of Biochemistry, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan) ,  Sudo Haruka (Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan)
Material： International Journal of Molecular Sciences (Web)  (Int J Mol Sci (Web))
Volume： 19  Issue： 9  Page： 2488  Publication year： 2018 
JST Material Number： U7038A  ISSN： 1422-0067  CODEN： IJMCFK  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Enhanced microtubule acetylati...

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Thesaurus term： spindle (cytology) ,  fluorescent antibody technique ,  human ,  sensitivity ,  Rattus ,  breast tumor ,  fibroblast ,  primary culture ,  *Acetylation ,  *Breast ,  Carcinogenesis ,  *microtubule ,  Mitosis ,  Aneuploidy ,  bioassay ,  Myomorpha
Semi thesaurus term： 腫瘍進行 , 【Automatic Indexing@JST】

Author keywords (5)： breast cancer ,  microtubule acetylation ,  microtubule severing ,  mitotic spindle ,  tau

JST classification (2)： Cell physiology in general  (EF02010S) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (48)：

• Song, Y.; Brady, S.T. Post-translational modifications of tubulin: Pathways to functional diversity of microtubules. Trends Cell Biol. 2015, 25, 125-136.
• Li, L.; Yang, X.J. Tubulin acetylation: Responsible enzymes, biological functions and human diseases. Cell Mol. Life Sci. 2015, 72, 4237-4255.
• Janke, C.; Montagnac, G. Causes and Consequences of Microtubule Acetylation. Curr. Biol. 2017, 27, R1287-R1292.
• Shida, T.; Cueva, J.G.; Xu, Z.; Goodman, M.B.; Nachury, M.V. The major alpha-tubulin K40 acetyltransferase αTAT1 promotes rapid ciliogenesis and efficient mechanosensation. Proc. Natl. Acad. Sci. USA 2010, 107, 21517-21522.
• Montagnac, G.; Meas-Yedid, V.; Irondelle, M.; Castro-Castro, A.; Franco, M.; Shida, T.; Nachury, M.V.; Benmerah, A.; Olivo-Marin, J.C.; Chavrier, P. αTAT1 catalyses microtubule acetylation at clathrin-coated pits. Nature 2013, 502, 567-570.

Terms in the title (8)： 微小管 ,  アセチル化 ,  乳房上皮細胞 ,  欠損 ,  依存性 ,  微小 ,  核形成 ,  増強