Art

J-GLOBAL ID：201902222900439055   Reference number：19A2336969

Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes

多発性骨髄腫のトランスクリプトーム全体の関連研究は候補感受性遺伝子を同定する【JST・京大機械翻訳】

Author (35)： Went Molly (Division of Genetics and Epidemiology, The Institute of Cancer Research, Surrey, UK) ,  Went Molly (Division of Molecular Pathology, The Institute of Cancer Research, Surrey, UK) ,  Kinnersley Ben (Division of Genetics and Epidemiology, The Institute of Cancer Research, Surrey, UK) ,  Sud Amit (Division of Genetics and Epidemiology, The Institute of Cancer Research, Surrey, UK) ,  Johnson David C. (Division of Molecular Pathology, The Institute of Cancer Research, Surrey, UK) ,  Weinhold Niels (Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany) ,  Forsti Asta (German Cancer Research Center, Heidelberg, Germany) ,  Duin Mark van (Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands) ,  Orlando Giulia (Division of Genetics and Epidemiology, The Institute of Cancer Research, Surrey, UK) ,  Mitchell Jonathan S. (Division of Genetics and Epidemiology, The Institute of Cancer Research, Surrey, UK) ,  Kuiper Rowan (Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands) ,  Walker Brian A. (Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, USA) ,  Gregory Walter M. (Clinical Trials Research Unit, University of Leeds, Leeds, UK) ,  Hoffmann Per (Institute of Human Genetics, University of Bonn, Bonn, Germany) ,  Hoffmann Per (Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland) ,  Jackson Graham H. (Royal Victoria Infirmary, Newcastle upon Tyne, UK) ,  Nothen Markus M. (Institute of Human Genetics, University of Bonn, Bonn, Germany) ,  Nothen Markus M. (Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany) ,  Filho Miguel Inacio da Silva (German Cancer Research Center, Heidelberg, Germany) ,  Thomsen Hauke (German Cancer Research Center, Heidelberg, Germany) ,  Broyl Annemiek (Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands) ,  Davies Faith E. (Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, USA) ,  Thorsteinsdottir Unnur (deCODE Genetics, Reykjavik, Iceland) ,  Hansson Markus (Hematology Clinic, Skane University Hospital, Lund, Sweden) ,  Hansson Markus (Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund, Sweden) ,  Kaiser Martin (Division of Molecular Pathology, The Institute of Cancer Research, Surrey, UK) ,  Sonneveld Pieter (Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, USA) ,  Goldschmidt Hartmut (Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany) ,  Goldschmidt Hartmut (Institute of Human Genetics, University of Bonn, Bonn, Germany) ,  Stefansson Kari (deCODE Genetics, Reykjavik, Iceland) ,  Hemminki Kari (German Cancer Research Center, Heidelberg, Germany) ,  Nilsson Bjorn (Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund, Sweden) ,  Nilsson Bjorn (Broad Institute, Cambridge, USA) ,  Morgan Gareth J. (Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, USA) ,  Houlston Richard S. (Division of Genetics and Epidemiology, The Institute of Cancer Research, Surrey, UK)
Material： Human Genomics (Web)
Volume： 13  Issue： 1  Page： 1-8  Publication year： 2019 
JST Material Number： U7322A  ISSN： 1479-7364  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： While genome-wide association ...

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Thesaurus term： *multiple myeloma ,  genotype ,  lymphocyte ,  *gene ,  tumorigenesis ,  multiplex ,  Genome-Wide Association Study ,  *transcriptome ,  gene expression
Semi thesaurus term： 悪性腫瘍 ,  候補遺伝子 ,  全血 ,  細胞株 ,  *ミエローマ ,  *感受性遺伝子 , 【Automatic Indexing@JST】

JST classification (5)： Cardiovascular system diseases  (GJ03000C) ,  Gene expression  (EC02040Q) ,  Basic neurology  (GN01020W) ,  Basic medicine on cardiovascular system  (GJ01020K) ,  Genetic variation  (EC01030Y)

Reference (41)：

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• Nat Commun; Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma; M Went, A Sud; 9; 1; 2018; 3707; 10.1038/s41467-018-04989-w; citation_id=CR2
• Nat Rev Cancer; Genome-wide association studies of cancer: current insights and future perspectives; A Sud, B Kinnersley, RS Houlston; 17; 11; 2017; 692-704; 10.1038/nrc.2017.82; citation_id=CR3
• Nat Genet; Principles for the post-GWAS functional characterization of cancer risk loci; ML Freedman, AN Monteiro, SA Gayther, GA Coetzee, A Risch, C Plass; 43; 6; 2011; 513-518; 10.1038/ng.840; citation_id=CR4
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Terms in the title (5)： 多発性骨髄腫 ,  トランスクリプトーム ,  研究 ,  感受性遺伝子 ,  同定