Art

J-GLOBAL ID：201902223733547834   Reference number：19A1344532

Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non-small cell lung cancer cells via Nrf2 inhibition

ジオスメチンはNrf2阻害を介して非小細胞肺癌細胞においてアポトーシスを誘導し,パクリタキセルの化学療法効果を増強する【JST・京大機械翻訳】

Author (30)： Chen Xiangcui (Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China) ,  Chen Xiangcui (Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou, China) ,  Chen Xiangcui (Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China) ,  Wu Qipeng (Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China) ,  Wu Qipeng (Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou, China) ,  Wu Qipeng (Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China) ,  Chen Yueming (Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China) ,  Chen Yueming (Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou, China) ,  Chen Yueming (Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China) ,  Zhang Jiahao (Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China) ,  Zhang Jiahao (Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou, China) ,  Zhang Jiahao (Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China) ,  Li Huachao (Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China) ,  Li Huachao (Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou, China) ,  Li Huachao (Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China) ,  Yang Zhicheng (Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China) ,  Yang Zhicheng (Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou, China) ,  Yang Zhicheng (Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China) ,  Yang Yang (Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China) ,  Yang Yang (Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou, China) ,  Yang Yang (Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China) ,  Deng Yanchao (Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China) ,  Deng Yanchao (Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou, China) ,  Deng Yanchao (Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China) ,  Zhang Luyong (Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou, China) ,  Zhang Luyong (Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China) ,  Zhang Luyong (The Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, China) ,  Liu Bing (Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China) ,  Liu Bing (Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou, China) ,  Liu Bing (Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China)
Material： British Journal of Pharmacology  (Br J Pharmacol)
Volume： 176  Issue： 12  Page： 2079-2094  Publication year： 2019 
JST Material Number： B0334A  ISSN： 0007-1188  CODEN： BJPCB  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： BACKGROUND AND PURPOSE: Non-sm...

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Thesaurus term： Western blotting ,  *non-small cell lung cancer ,  mRNA ,  in vitro experiment ,  spleen ,  heterotrans plantation ,  *apoptosis ,  flavonoid ,  flow cytometry ,  human(primates) ,  toxicity ,  antitumor action ,  protein ,  alicyclic compound ,  fatty acid ,  aromatic carboxylic acid ,  oxygen heterocyclic compound ,  olefin compound ,  bridged compound ,  carboxylate(ester) ,  aminoalcohol ,  aminocarboxylic acid ,  secondary alcohol ,  hydroxy acid ,  hydroxy ketone ,  polyol ,  polyphenol ,  phenol ether ,  polynuclear aromatic compound
Semi thesaurus term： *NFE2関連因子2 , 【Automatic Indexing@JST】

JST classification (2)： Basic research of psychotropic drugs  (GW03100Y) ,  Basic research of anti-inflammatory drugs  (GW15010T)

Substance index (2)： Paclitaxel ,  Diosmetin

Terms in the title (10)： ジオスメチン ,  NRF2 ,  阻害 ,  非小細胞肺癌 ,  細胞 ,  アポトーシス ,  誘導 ,  パクリタキセル ,  化学療法 ,  増強