Art

J-GLOBAL ID：201902224024132122   Reference number：19A1321630

Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction

mTORC2ではなくmTORC1の薬理学的阻害はAktおよびオートファジー誘導を介してヒト椎間板細胞アポトーシス,老化および細胞外マトリックス異化を保護する【JST・京大機械翻訳】

Author (10)： Kakiuchi Y. (Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Yurube T. (Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Kakutani K. (Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Takada T. (Department of Orthopaedic Surgery, Kenshinkai Kobe Hokuto Hospital, 37-3 Yamada-cho Shimotanigami Aza Umekidani, Kita-ku, Kobe 651-1243, Japan) ,  Ito M. (Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Takeoka Y. (Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Kanda Y. (Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Miyazaki S. (Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Kuroda R. (Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Nishida K. (Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan)
Material： Osteoarthritis and Cartilage
Volume： 27  Issue： 6  Page： 965-976  Publication year： 2019 
JST Material Number： W3157A  ISSN： 1063-4584  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The mammalian target of rapamy...

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Thesaurus term： phosphorylation ,  Inflammation ,  interleukin 1 ,  Cell Proliferation ,  light chain ,  *Autophagy ,  *dissimilation ,  *Apoptosis ,  *human ,  protective action ,  *TOR Serine-Threonine Kinases ,  *Akt/protein kinase B ,  *mTORC1 ,  ether ,  macrocyclic compound ,  lactam ,  lactone ,  enzyme inhibitor ,  hemiacetal ,  alicyclic alcohol ,  secondary alcohol ,  hydroxy ketone
Semi thesaurus term： 阻害剤 , 【Automatic Indexing@JST】

Author keywords (6)： Intervertebral disc ,  Nucleus pulposus cells ,  Mammalian target of rapamycin (mTOR) ,  Akt ,  Autophagy ,  Spine

JST classification (2)： Basic medicine on musculoskeletal system  (GG01020B) ,  Skeletal system  (EJ10030R)

Substance index (1)： Sirolimus

Terms in the title (13)： mTORC2 ,  mTORC1 ,  薬理学 ,  阻害 ,  Akt ,  オートファジー ,  誘導 ,  ヒト ,  椎間板細胞 ,  アポトーシス ,  老化 ,  細胞外マトリックス ,  異化