Art

J-GLOBAL ID：201902225381735359   Reference number：19A2733799

Potentiation of Glucagon-Like Peptide-2 Dynamics by Methotrexate Administration in Rat Small Intestine

ラット小腸におけるメトトレキサート投与によるグルカゴン様ペプチド-2動態の増強

Author (6)： Machida Maiko (Division of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Hokkaido University of Science) ,  Shiga Saki (Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido) ,  Machida Takuji (Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido) ,  Ohno Masafumi (Division of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Hokkaido University of Science) ,  Iizuka Kenji (Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido) ,  Hirafuji Masahiko (Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 10  Page： 1733-1740(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： Transforming Growth Factor beta2 ,...

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Author keywords (10)： methotrexate ,  5-fluorouracil ,  glucagon-like peptide-2 ,  chemotherapy-induced mucositis ,  insulin-like growth factor-1 ,  methotrexate ,  5-fluorouracil ,  glucagon-like peptide-2 ,  chemotherapy-induced mucositis ,  insulin-like growth factor-1

JST classification (2)： Basic medicine on digestive system  (GH01020E) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： Fluorouracil ,  Methotrexate

Reference (36)：

• 1) Gaté L, Paul J, Ba GN, Tew KD, Tapiero H. Oxidative stress induced in pathologies: the role of antioxidants. Biomed. Pharmacother., 53, 169-180 (1999).
• 2) Trier JS. Morphologic alterations induced by methotrexate in the mucosa of human proximal intestine. II. Electron microscopic observations. Gastroenterology, 43, 407-424 (1962).
• 3) Keefe DM, Brealey J, Goland GJ, Cummins AG. Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans. Gut, 47, 632-637 (2000).
• 4) Keefe DM. Gastrointestinal mucositis: a new biological model. Support. Care Cancer, 12, 6-9 (2004).
• 5) Drucker DJ, Yusta B. Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2. Annu. Rev. Physiol., 76, 560-583 (2014).

Terms in the title (6)： ラット ,  小腸 ,  メトトレキサート ,  投与 ,  グルカゴン様ペプチド-2 ,  増強