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J-GLOBAL ID：201902225510126726   Reference number：19A2869080

Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells

グループA Streptococcus NAD-グリコヒドロラーゼはヒト上皮細胞へのカベオリン1仲介インターナリゼーションを阻害する【JST・京大機械翻訳】

Author (7)： Toh Hirotaka (Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Lin Ching-Yu (Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Nakajima Shintaro (Department of Life Science Dentistry, The Nippon Dental University, Tokyo, Japan) ,  Nakajima Shintaro (Department of Developmental and Regenerative Dentistry, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan) ,  Aikawa Chihiro (Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Nozawa Takashi (Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Nakagawa Ichiro (Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan)
Material： Frontiers in Cellular and Infection Microbiology (Web)
Volume： 9  Page： 398  Publication year： 2019 
JST Material Number： U7063A  ISSN： 2235-2988  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Group A Streptococcus (GAS) in...

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Thesaurus term： HeLa cell ,  cytotoxicity ,  *Streptococcus ,  *human(primates) ,  *epithelial cell ,  *internalization ,  wild type ,  NAD nucleosidase ,  adenine nucleotide ,  nicotinamide mononucleotide
Semi thesaurus term： *カベオリン ,  調節因子 ,  宿主細胞 ,  アミノ酸置換 ,  エフェクタ蛋白質 ,  *カベオリン1 , 【Automatic Indexing@JST】

Author keywords (5)： Group A Streptoccocus ,  internalization ,  CAV1 (caveolin-1) ,  NAD-glycohydrolase ,  Streptolysin O (SLO)

JST classification (2)： Physiology and pathogenicity of microbial infection  (EG03053T) ,  Biological function  (EB03040U)

Substance index (1)： NADPH

Reference (64)：

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• Bastiat-Sempe B., Love J. F., Lomayesva N., Wessels M. R. (2014). Streptolysin O and NAD-glycohydrolase prevent phagolysosome acidification and promote group A Streptococcus survival in macrophages. MBio 5, e01690-e01614. doi: 10.1128/mBio.01690-14
• Bricker A. L., Cywes C., Ashbaugh C. D., Wessels M. R. (2002). NAD+-glycohydrolase acts as an intracellular toxin to enhance the extracellular survival of group A streptococci. Mol. Microbiol. 44, 257-269. doi: 10.1046/j.1365-2958.2002.02876.x

Terms in the title (10)： グループ ,  Streptococcus ,  NAD ,  ヒドロラーゼ ,  ヒト ,  上皮細胞 ,  カベオリン1 ,  仲介 ,  インターナリゼーション ,  阻害